Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study
Abstract Introduction Ultrasound for the brain is a revolutionary therapeutic concept. The first clinical data indicate that 2–4 weeks of therapy with transcranial pulse stimulation (TPS) improve functional networks and cognitive performance of Alzheimer's disease (AD) patients for up to 3 mont...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12121 |
| _version_ | 1797984973206061056 |
|---|---|
| author | Tudor Popescu Cyril Pernet Roland Beisteiner |
| author_facet | Tudor Popescu Cyril Pernet Roland Beisteiner |
| author_sort | Tudor Popescu |
| collection | DOAJ |
| description | Abstract Introduction Ultrasound for the brain is a revolutionary therapeutic concept. The first clinical data indicate that 2–4 weeks of therapy with transcranial pulse stimulation (TPS) improve functional networks and cognitive performance of Alzheimer's disease (AD) patients for up to 3 months. No data currently exist on possible benefits concerning brain morphology, namely the cortical atrophy characteristic of AD. Methods We performed a pre‐/post‐therapy analysis of cortical thickness in a group of N = 17 AD patients. Results We found a significant correlation between neuropsychological improvement and cortical thickness increase in AD‐critical brain areas. Discussion AD patients who benefit from TPS appear to manifest reduced cortical atrophy within the default mode network in particular, whose memory‐related subsystems are believed to be disrupted in AD. TPS may therefore hold promise as a new add‐on therapy for AD. |
| first_indexed | 2024-04-11T07:10:20Z |
| format | Article |
| id | doaj.art-9417773a99134250ba33bfdb69fdcbbb |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-11T07:10:20Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-9417773a99134250ba33bfdb69fdcbbb2022-12-22T04:38:14ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12121Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up studyTudor Popescu0Cyril Pernet1Roland Beisteiner2Department of Behavioural and Cognitive Biology University of Vienna Vienna AustriaCentre for Clinical Brain Sciences University of Edinburgh Edinburgh UKDepartment of Neurology Medical University of Vienna Vienna AustriaAbstract Introduction Ultrasound for the brain is a revolutionary therapeutic concept. The first clinical data indicate that 2–4 weeks of therapy with transcranial pulse stimulation (TPS) improve functional networks and cognitive performance of Alzheimer's disease (AD) patients for up to 3 months. No data currently exist on possible benefits concerning brain morphology, namely the cortical atrophy characteristic of AD. Methods We performed a pre‐/post‐therapy analysis of cortical thickness in a group of N = 17 AD patients. Results We found a significant correlation between neuropsychological improvement and cortical thickness increase in AD‐critical brain areas. Discussion AD patients who benefit from TPS appear to manifest reduced cortical atrophy within the default mode network in particular, whose memory‐related subsystems are believed to be disrupted in AD. TPS may therefore hold promise as a new add‐on therapy for AD.https://doi.org/10.1002/trc2.12121Alzheimer's diseasebrain stimulationcortical atrophycortical thicknessdefault mode networkultrasound |
| spellingShingle | Tudor Popescu Cyril Pernet Roland Beisteiner Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease brain stimulation cortical atrophy cortical thickness default mode network ultrasound |
| title | Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study |
| title_full | Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study |
| title_fullStr | Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study |
| title_full_unstemmed | Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study |
| title_short | Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow‐up study |
| title_sort | transcranial ultrasound pulse stimulation reduces cortical atrophy in alzheimer s patients a follow up study |
| topic | Alzheimer's disease brain stimulation cortical atrophy cortical thickness default mode network ultrasound |
| url | https://doi.org/10.1002/trc2.12121 |
| work_keys_str_mv | AT tudorpopescu transcranialultrasoundpulsestimulationreducescorticalatrophyinalzheimerspatientsafollowupstudy AT cyrilpernet transcranialultrasoundpulsestimulationreducescorticalatrophyinalzheimerspatientsafollowupstudy AT rolandbeisteiner transcranialultrasoundpulsestimulationreducescorticalatrophyinalzheimerspatientsafollowupstudy |