Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells

Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key factor in several cardiovascular diseases, as it is responsible for the elevation of circulating low-density lipoprotein cholesterol (LDL-C) levels in blood plasma by direct interaction with the LDL receptor. The development of orally av...

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Bibliographic Details
Main Authors: Jagadeesh Nagarajappa Masagalli, Melanayakanakatte Kuberappa BasavanaGowda, Hee-Sung Chae, Won Jun Choi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
proprotein convertase subtilisin/kexin type 9
low-density lipoprotein cholesterol
cardiovascular diseases
moracin compounds
structure activity relationships
HepG2 cell lines
Online Access:https://www.mdpi.com/1420-3049/26/5/1327

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