Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization
In this study, a novel strategy was established to produce diosgenin from Discorea nipponica Makino tubers, in which pressurized biphase acid hydrolysis and Soxhlet extraction of total saponins were incorporated for the first time. The hydrolysis conditions were optimized by response surface methodo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2019.1579370 |
| _version_ | 1828530024796389376 |
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| author | Changjie Yu Zihao Li Huawu Yin Guohua Xia Yuping Shen Huan Yang Jing Gao Xiaobin Jia |
| author_facet | Changjie Yu Zihao Li Huawu Yin Guohua Xia Yuping Shen Huan Yang Jing Gao Xiaobin Jia |
| author_sort | Changjie Yu |
| collection | DOAJ |
| description | In this study, a novel strategy was established to produce diosgenin from Discorea nipponica Makino tubers, in which pressurized biphase acid hydrolysis and Soxhlet extraction of total saponins were incorporated for the first time. The hydrolysis conditions were optimized by response surface methodology after the preliminary investigation on affecting factors by single-factor experiments and L16(45) orthogonal experiments. Under the optimal conditions, namely dioscin (eq. 8 g of the DNM tubers) was hydrolyzed in a biphase system composed of 50 mL of 6 μL/mL H2SO4 solution and 50 mL of petroleum ether (90–120°C) at 140°C for 2 h, the highest yield of diosgenin has been achieved at 1.87%, that was 85.1% higher than the conventional method while the H2SO4 consumption reduced by 92.5%. The results demonstrated that the newly developed approach was more effective and cleaner, and promising value-added technology for the extraction of diosgenin from DNM tubers in industrial application. |
| first_indexed | 2024-12-11T22:17:14Z |
| format | Article |
| id | doaj.art-9418dc0c0ec944c59163ac947ff20423 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-12-11T22:17:14Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-9418dc0c0ec944c59163ac947ff204232022-12-22T00:48:33ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922019-01-01121798810.1080/17518253.2019.15793701579370Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimizationChangjie Yu0Zihao Li1Huawu Yin2Guohua Xia3Yuping Shen4Huan Yang5Jing Gao6Xiaobin Jia7School of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversitySchool of Pharmacy, Jiangsu UniversityIn this study, a novel strategy was established to produce diosgenin from Discorea nipponica Makino tubers, in which pressurized biphase acid hydrolysis and Soxhlet extraction of total saponins were incorporated for the first time. The hydrolysis conditions were optimized by response surface methodology after the preliminary investigation on affecting factors by single-factor experiments and L16(45) orthogonal experiments. Under the optimal conditions, namely dioscin (eq. 8 g of the DNM tubers) was hydrolyzed in a biphase system composed of 50 mL of 6 μL/mL H2SO4 solution and 50 mL of petroleum ether (90–120°C) at 140°C for 2 h, the highest yield of diosgenin has been achieved at 1.87%, that was 85.1% higher than the conventional method while the H2SO4 consumption reduced by 92.5%. The results demonstrated that the newly developed approach was more effective and cleaner, and promising value-added technology for the extraction of diosgenin from DNM tubers in industrial application.http://dx.doi.org/10.1080/17518253.2019.1579370diosgenindiscorea nipponica makinogreen productionresponse surface methodologypressurized biphase acid hydrolysis |
| spellingShingle | Changjie Yu Zihao Li Huawu Yin Guohua Xia Yuping Shen Huan Yang Jing Gao Xiaobin Jia Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization Green Chemistry Letters and Reviews diosgenin discorea nipponica makino green production response surface methodology pressurized biphase acid hydrolysis |
| title | Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| title_full | Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| title_fullStr | Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| title_full_unstemmed | Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| title_short | Green production of diosgenin from Discorea nipponica Makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| title_sort | green production of diosgenin from discorea nipponica makino tubers based on pressurized biphase acid hydrolysis via response surface methodology optimization |
| topic | diosgenin discorea nipponica makino green production response surface methodology pressurized biphase acid hydrolysis |
| url | http://dx.doi.org/10.1080/17518253.2019.1579370 |
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