Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study
Background“Emergency Room Evaluation and Recommendations” (ER2) risk levels (i.e., low, moderate and high) may be used to screen for major neurocognitive disorders (MNCD) in older emergency department users, as a high ER2 risk level is associated with MNCD diagnosis. This study aims to examine the a...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.912477/full |
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| author | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Jacqueline Matskiv Cyrille P. Launay Yves Rolland Anne-Marie Schott Gilles Allali |
| author_facet | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Jacqueline Matskiv Cyrille P. Launay Yves Rolland Anne-Marie Schott Gilles Allali |
| author_sort | Olivier Beauchet |
| collection | DOAJ |
| description | Background“Emergency Room Evaluation and Recommendations” (ER2) risk levels (i.e., low, moderate and high) may be used to screen for major neurocognitive disorders (MNCD) in older emergency department users, as a high ER2 risk level is associated with MNCD diagnosis. This study aims to examine the association of ER2 risk levels with incident MNCD in community-dwelling older adults.MethodsA total of 709 participants of the EPIDémiologie de l’OStéoporose (EPIDOS) study—an observational population-based cohort study—were recruited in Toulouse (France). ER2 low, moderate and high risk levels were determined at baseline. Incident MNCD and their type (i.e., Alzheimer’s disease (AD) vs. non-AD) were diagnosed after a 7-year follow-up period.ResultsThe overall incidence of MNCD was 29.1%. A low ER2 risk level was associated with low incidence of MNCD [Hazard ratio (HR) = 0.71 with P = 0.018] and AD (HR = 0.56 with P = 0.003), whereas a high risk level, both individually and when combined with a moderate risk level, was associated with high incidence of MNCD (HR ≥ 1.40 with P ≤0.018) and AD (HR ≥ 1.80 with P ≤ 0.003). No association was found with incident non-AD.ConclusionER2 risk levels were positively associated with incident MNCD in EPIDOS participants, suggesting that ER2 may be used for risk screening of MNCD in the older population. |
| first_indexed | 2024-12-12T00:01:15Z |
| format | Article |
| id | doaj.art-9419a2ae2fc445f384907ee957918a9f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T00:01:15Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9419a2ae2fc445f384907ee957918a9f2022-12-22T00:45:13ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-07-011410.3389/fnagi.2022.912477912477Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort StudyOlivier Beauchet0Olivier Beauchet1Olivier Beauchet2Olivier Beauchet3Jacqueline Matskiv4Cyrille P. Launay5Yves Rolland6Anne-Marie Schott7Gilles Allali8Department of Medicine and Geriatrics, University of Montreal, Montreal, QC, CanadaResearch Centre of the Geriatric University Institute of Montreal, Montreal, QC, CanadaDivision of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, CanadaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeResearch Centre of the Geriatric University Institute of Montreal, Montreal, QC, CanadaDivision of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, CanadaDepartment of Geriatric, Toulouse University Hospital, Toulouse, FranceUniversité Claude Bernard Lyon1, Unité INSERM 1290 RESHAPE, Hospices Civils de Lyon, Pôle de Santé Publique, Lyon, FranceLeenaards Memory Center, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandBackground“Emergency Room Evaluation and Recommendations” (ER2) risk levels (i.e., low, moderate and high) may be used to screen for major neurocognitive disorders (MNCD) in older emergency department users, as a high ER2 risk level is associated with MNCD diagnosis. This study aims to examine the association of ER2 risk levels with incident MNCD in community-dwelling older adults.MethodsA total of 709 participants of the EPIDémiologie de l’OStéoporose (EPIDOS) study—an observational population-based cohort study—were recruited in Toulouse (France). ER2 low, moderate and high risk levels were determined at baseline. Incident MNCD and their type (i.e., Alzheimer’s disease (AD) vs. non-AD) were diagnosed after a 7-year follow-up period.ResultsThe overall incidence of MNCD was 29.1%. A low ER2 risk level was associated with low incidence of MNCD [Hazard ratio (HR) = 0.71 with P = 0.018] and AD (HR = 0.56 with P = 0.003), whereas a high risk level, both individually and when combined with a moderate risk level, was associated with high incidence of MNCD (HR ≥ 1.40 with P ≤0.018) and AD (HR ≥ 1.80 with P ≤ 0.003). No association was found with incident non-AD.ConclusionER2 risk levels were positively associated with incident MNCD in EPIDOS participants, suggesting that ER2 may be used for risk screening of MNCD in the older population.https://www.frontiersin.org/articles/10.3389/fnagi.2022.912477/fullolder adultsepidemiologycohort studydementiaincidence |
| spellingShingle | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Jacqueline Matskiv Cyrille P. Launay Yves Rolland Anne-Marie Schott Gilles Allali Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study Frontiers in Aging Neuroscience older adults epidemiology cohort study dementia incidence |
| title | Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study |
| title_full | Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study |
| title_fullStr | Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study |
| title_full_unstemmed | Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study |
| title_short | Emergency Room Evaluation and Recommendations and Risk Screening of Incident Major Neurocognitive Disorders in Older Females: Results of an Observational Population-Based Cohort Study |
| title_sort | emergency room evaluation and recommendations and risk screening of incident major neurocognitive disorders in older females results of an observational population based cohort study |
| topic | older adults epidemiology cohort study dementia incidence |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.912477/full |
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