Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we examined the effect of periprostatic adipose tissue supernatant obtained from obese mice on prostate reactivity in vitro and on the vi...

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Bibliographic Details
Main Authors: Gabriela Reolon Passos, Mariana G. de Oliveira, Ana Carolina Ghezzi, Glaucia C. Mello, Carlos Arturo Levi D’Ancona, Simone Aparecida Teixeira, Marcelo Nicolas Muscará, Carla Beatriz Grespan Bottoli, Lucilia Vilela de Melo, Eliezer de Oliveira, Edson Antunes, Fabiola Zakia Mónica
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
adenosine
benign prostatic hyperplasia
cell proliferation
nitric oxide
obesity
PPAT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1145860/full

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