HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE

The article deals with the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokine, cyclins and other mediators of the...

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Main Authors: N. V. Pizova, N. A. Pizo
Format: Article
Language:Russian
Published: Remedium Group LLC 2017-05-01
Series:Медицинский совет
Subjects:
Online Access:https://www.med-sovet.pro/jour/article/view/1861
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author N. V. Pizova
N. A. Pizo
author_facet N. V. Pizova
N. A. Pizo
author_sort N. V. Pizova
collection DOAJ
description The article deals with the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokine, cyclins and other mediators of the inflammation. Its accumulation results in the loosening of arterial walls, formation of local defects in endothelium, which in turn leads to deposition on the cardiovascular wall of cholesterol and calcium. Hyperhomocysteinemia as a consequence of disturbed homocysteine metabolism is considered an independent factor in the risk of human stroke. The role of neuroprotective therapy in interrupting or decelerating the sequence of damaging biochemical and molecular processes capable of causing irreversible coronary damage to the brain is demonstrated.
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spelling doaj.art-941c7ce0f4ba406fbeab01053122ea9c2023-04-23T06:57:09ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902017-05-01010121710.21518/2079-701X-2017-10-12-171838HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKEN. V. Pizova0N. A. Pizo1Yaroslavl State Medical UniversityYaroslavl State Medical UniversityThe article deals with the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokine, cyclins and other mediators of the inflammation. Its accumulation results in the loosening of arterial walls, formation of local defects in endothelium, which in turn leads to deposition on the cardiovascular wall of cholesterol and calcium. Hyperhomocysteinemia as a consequence of disturbed homocysteine metabolism is considered an independent factor in the risk of human stroke. The role of neuroprotective therapy in interrupting or decelerating the sequence of damaging biochemical and molecular processes capable of causing irreversible coronary damage to the brain is demonstrated.https://www.med-sovet.pro/jour/article/view/1861homocysteinehyperhomocysteinemiaischemic strokeneuroprotection
spellingShingle N. V. Pizova
N. A. Pizo
HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
Медицинский совет
homocysteine
hyperhomocysteinemia
ischemic stroke
neuroprotection
title HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
title_full HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
title_fullStr HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
title_full_unstemmed HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
title_short HYPERHOMOCYSTEINEMIA AND ISCHEMIC STROKE
title_sort hyperhomocysteinemia and ischemic stroke
topic homocysteine
hyperhomocysteinemia
ischemic stroke
neuroprotection
url https://www.med-sovet.pro/jour/article/view/1861
work_keys_str_mv AT nvpizova hyperhomocysteinemiaandischemicstroke
AT napizo hyperhomocysteinemiaandischemicstroke