Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80
We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonan...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2020-01-01
|
| Series: | Case Reports in Neurology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/505231 |
| _version_ | 1818518767344287744 |
|---|---|
| author | Shunya Fujiwara Yasuhiro Manabe Ryuta Morihara Taijun Yunoki Syoichiro Kono Hisashi Narai Koji Abe |
| author_facet | Shunya Fujiwara Yasuhiro Manabe Ryuta Morihara Taijun Yunoki Syoichiro Kono Hisashi Narai Koji Abe |
| author_sort | Shunya Fujiwara |
| collection | DOAJ |
| description | We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important. |
| first_indexed | 2024-12-11T01:14:47Z |
| format | Article |
| id | doaj.art-941d8f2e56f44456984ec5213194ac1c |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-12-11T01:14:47Z |
| publishDate | 2020-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-941d8f2e56f44456984ec5213194ac1c2022-12-22T01:25:56ZengKarger PublishersCase Reports in Neurology1662-680X2020-01-01121131710.1159/000505231505231Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80Shunya FujiwaraYasuhiro ManabeRyuta MoriharaTaijun YunokiSyoichiro KonoHisashi NaraiKoji AbeWe report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important.https://www.karger.com/Article/FullText/505231neuromyelitis opticavery late onsetanti-aquaporin-4 antibodytransverse myelopathy |
| spellingShingle | Shunya Fujiwara Yasuhiro Manabe Ryuta Morihara Taijun Yunoki Syoichiro Kono Hisashi Narai Koji Abe Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 Case Reports in Neurology neuromyelitis optica very late onset anti-aquaporin-4 antibody transverse myelopathy |
| title | Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 |
| title_full | Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 |
| title_fullStr | Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 |
| title_full_unstemmed | Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 |
| title_short | Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80 |
| title_sort | two cases of very late onset neuromyelitis optica spectrum disorder nmosd in patients over the age of 80 |
| topic | neuromyelitis optica very late onset anti-aquaporin-4 antibody transverse myelopathy |
| url | https://www.karger.com/Article/FullText/505231 |
| work_keys_str_mv | AT shunyafujiwara twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT yasuhiromanabe twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT ryutamorihara twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT taijunyunoki twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT syoichirokono twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT hisashinarai twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 AT kojiabe twocasesofverylateonsetneuromyelitisopticaspectrumdisordernmosdinpatientsovertheageof80 |