Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine
ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the e...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2022-01-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601&tlng=en |
| _version_ | 1823964898561884160 |
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| author | Lucas Valeiras Gaddini Carlos Rodrigo Komatsu de Alencar Taina Lorraine Pereira Azevedo Gabriela Geraldo de Lima Rubia Mitalli Tomacheuski Marcos Ferrante Marilda Onghero Taffarel |
| author_facet | Lucas Valeiras Gaddini Carlos Rodrigo Komatsu de Alencar Taina Lorraine Pereira Azevedo Gabriela Geraldo de Lima Rubia Mitalli Tomacheuski Marcos Ferrante Marilda Onghero Taffarel |
| author_sort | Lucas Valeiras Gaddini |
| collection | DOAJ |
| description | ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 µg/kg of detomidine alone (IMD) and intramuscular administration of 30 µg/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn’s post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. IMDM promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD. |
| first_indexed | 2024-12-17T17:49:45Z |
| format | Article |
| id | doaj.art-941dbf17f0e8420a940bf5c96ba0e795 |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-17T17:49:45Z |
| publishDate | 2022-01-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-941dbf17f0e8420a940bf5c96ba0e7952022-12-21T21:38:51ZengUniversidade Federal de Santa MariaCiência Rural1678-45962022-01-0152810.1590/0103-8478cr20200828Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphineLucas Valeiras Gaddinihttps://orcid.org/0000-0002-5763-3904Carlos Rodrigo Komatsu de AlencarTaina Lorraine Pereira AzevedoGabriela Geraldo de LimaRubia Mitalli Tomacheuskihttps://orcid.org/0000-0002-7967-0124Marcos Ferrantehttps://orcid.org/0000-0001-6979-2956Marilda Onghero Taffarelhttps://orcid.org/0000-0002-6643-3461ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 µg/kg of detomidine alone (IMD) and intramuscular administration of 30 µg/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn’s post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. IMDM promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601&tlng=endeep sedationhorseshypnotics and sedativesdetomidinemorphine |
| spellingShingle | Lucas Valeiras Gaddini Carlos Rodrigo Komatsu de Alencar Taina Lorraine Pereira Azevedo Gabriela Geraldo de Lima Rubia Mitalli Tomacheuski Marcos Ferrante Marilda Onghero Taffarel Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine Ciência Rural deep sedation horses hypnotics and sedatives detomidine morphine |
| title | Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| title_full | Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| title_fullStr | Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| title_full_unstemmed | Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| title_short | Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| title_sort | sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
| topic | deep sedation horses hypnotics and sedatives detomidine morphine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601&tlng=en |
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