Enkephalin Leucine Microspheres Suspension as a Sustained Antiplaque Antimicrobial Delivery System
The purpose of this study is to prepare a formulation containing enkephalin leucine as an antiplaque/antibacterial agent. Enkephalin leucine microspheres were prepared using a poly(D-L-lactide-co-glycolide) (PLGA) as a delivery system. The microspheres were prepared by a dispersion/solvent extracti...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2010-06-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/315 |
| Summary: | The purpose of this study is to prepare a formulation containing enkephalin leucine as an antiplaque/antibacterial agent. Enkephalin leucine microspheres were prepared using a poly(D-L-lactide-co-glycolide) (PLGA) as a delivery system. The microspheres were prepared by a dispersion/solvent extraction evaporation method and characterized for drug load by HPLC, particle size by laser diffractometry and surface morphology by scanning electron microscopy (SEM). In vitro enkephalin leucine release was studied using a dialysis method. The stability of peptide in human saliva was concentration dependent. PLGA microspheres had released after socking in the artificial saliva. The encapsulation efficiency was around 83% -97% with the spherical shape. The in vitro release was successfully controlled over 60 minute or more with percentage of release reach to 70% for the free drug & 25% for the adsorbed drug.
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| ISSN: | 1815-0993 2959-183X |