G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer
<p>Abstract</p> <p>Background</p> <p>G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 expression in tissue speci...
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| Format: | Article |
| Language: | English |
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BMC
2004-11-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/4/79 |
| _version_ | 1818682895012724736 |
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| author | Takanami Iwao Inoue Yoshimasa Gika Masatoshi |
| author_facet | Takanami Iwao Inoue Yoshimasa Gika Masatoshi |
| author_sort | Takanami Iwao |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 expression in tissue specimens from patients with non-small cell lung cancers (NSCLCs) and assessed their clinical characteristics.</p> <p>Methods</p> <p>Using reverse transcription-polymerase chain reaction (RT-PCR) analyses, we quantified the expression of GIRK1 in 72 patients with NSCLCs to investigate the relationship between GIRK1 expression and clinicopathologic factors and prognosis.</p> <p>Results</p> <p>In 72 NSCLC patients, 50 (69%) samples were evaluated as having high GIRK1 gene expression, and 22 (31%) were evaluated as having low GIRK1 gene expression. GIRK1 gene expression was significantly associated with lymph node metastasis, stage (p = 0.0194 for lymph node metastasis; p = 0.0207 for stage). The overall and stage I survival rates for patients with high GIRK1 gene expressed tumors was significantly worse than for those individuals whose tumors had low GIRK1 expression (p = 0.0004 for the overall group; p = 0.0376 for stage I).</p> <p>Conclusions</p> <p>These data indicate that GIRK1 may contribute to tumor progression and GIRK1 gene expression can serve as a useful prognostic marker in the overall and stage I NSCLCs.</p> |
| first_indexed | 2024-12-17T10:26:06Z |
| format | Article |
| id | doaj.art-941f0130c55a4e8cbdd6e33b18ff3aef |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-17T10:26:06Z |
| publishDate | 2004-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-941f0130c55a4e8cbdd6e33b18ff3aef2022-12-21T21:52:40ZengBMCBMC Cancer1471-24072004-11-01417910.1186/1471-2407-4-79G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancerTakanami IwaoInoue YoshimasaGika Masatoshi<p>Abstract</p> <p>Background</p> <p>G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 expression in tissue specimens from patients with non-small cell lung cancers (NSCLCs) and assessed their clinical characteristics.</p> <p>Methods</p> <p>Using reverse transcription-polymerase chain reaction (RT-PCR) analyses, we quantified the expression of GIRK1 in 72 patients with NSCLCs to investigate the relationship between GIRK1 expression and clinicopathologic factors and prognosis.</p> <p>Results</p> <p>In 72 NSCLC patients, 50 (69%) samples were evaluated as having high GIRK1 gene expression, and 22 (31%) were evaluated as having low GIRK1 gene expression. GIRK1 gene expression was significantly associated with lymph node metastasis, stage (p = 0.0194 for lymph node metastasis; p = 0.0207 for stage). The overall and stage I survival rates for patients with high GIRK1 gene expressed tumors was significantly worse than for those individuals whose tumors had low GIRK1 expression (p = 0.0004 for the overall group; p = 0.0376 for stage I).</p> <p>Conclusions</p> <p>These data indicate that GIRK1 may contribute to tumor progression and GIRK1 gene expression can serve as a useful prognostic marker in the overall and stage I NSCLCs.</p>http://www.biomedcentral.com/1471-2407/4/79 |
| spellingShingle | Takanami Iwao Inoue Yoshimasa Gika Masatoshi G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer BMC Cancer |
| title | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer |
| title_full | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer |
| title_fullStr | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer |
| title_full_unstemmed | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer |
| title_short | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer |
| title_sort | g protein inwardly rectifying potassium channel 1 girk 1 gene expression correlates with tumor progression in non small cell lung cancer |
| url | http://www.biomedcentral.com/1471-2407/4/79 |
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