Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood–Brain Barrier Model and Entry to Human Brain Organoids

Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood–Brain Barrier Model and Entry to Human Brain Organoids

Nanoparticles (NPs) are the focus of research efforts that aim to develop successful drug delivery systems for the brain. Polypeptide nanocarriers are versatile platforms and combine high functionality with good biocompatibility and biodegradability. The key to the efficient brain delivery of NPs is...

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Bibliographic Details
Main Authors: Mária Mészáros, Thi Ha My Phan, Judit P. Vigh, Gergő Porkoláb, Anna Kocsis, Emese K. Páli, Tamás F. Polgár, Fruzsina R. Walter, Silvia Bolognin, Jens C. Schwamborn, Jeng-Shiung Jan, Mária A. Deli, Szilvia Veszelka
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
brain endothelial cells
blood–brain barrier
brain organoid
peptide nanocarriers
3-armed polypeptides
alanine
Online Access:https://www.mdpi.com/2073-4409/12/3/503

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