Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibr...
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/12/3217 |
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| author | Patrycja Ledwoń Anna Maria Papini Paolo Rovero Rafal Latajka |
| author_facet | Patrycja Ledwoń Anna Maria Papini Paolo Rovero Rafal Latajka |
| author_sort | Patrycja Ledwoń |
| collection | DOAJ |
| description | Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibrotic process and collagen accumulation results with joints, bone, heart, lungs, kidneys or liver fibroses. Per contra, dysfunctional collagen turnover and its increased degradation leads to wound healing disruption, skin photoaging, and loss of firmness and elasticity. In this review we described the main enzymes participating in collagen degradation pathway, paying particular attention to enzymes degrading fibrillar collagen. Therefore, collagenases (MMP-1, -8, and -13), elastases, and cathepsins, together with their peptide and peptidomimetic inhibitors, are reviewed. This information, related to the design and synthesis of new inhibitors based on peptide structure, can be relevant for future research in the fields of chemistry, biology, medicine, and cosmeceuticals. |
| first_indexed | 2024-03-10T10:31:24Z |
| format | Article |
| id | doaj.art-9423f047575f4f129c76310b7c39abf2 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T10:31:24Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-9423f047575f4f129c76310b7c39abf22023-11-21T23:38:24ZengMDPI AGMaterials1996-19442021-06-011412321710.3390/ma14123217Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen DegradationPatrycja Ledwoń0Anna Maria Papini1Paolo Rovero2Rafal Latajka3Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, PolandInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry “Ugo Schiff”, University of Florence, 50019 Sesto Fiorentino, Firenze, ItalyInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Neurosciences, Psychology, Drug Research and Child Health-Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, 50019 Sesto Fiorentino, Firenze, ItalyDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, PolandCollagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibrotic process and collagen accumulation results with joints, bone, heart, lungs, kidneys or liver fibroses. Per contra, dysfunctional collagen turnover and its increased degradation leads to wound healing disruption, skin photoaging, and loss of firmness and elasticity. In this review we described the main enzymes participating in collagen degradation pathway, paying particular attention to enzymes degrading fibrillar collagen. Therefore, collagenases (MMP-1, -8, and -13), elastases, and cathepsins, together with their peptide and peptidomimetic inhibitors, are reviewed. This information, related to the design and synthesis of new inhibitors based on peptide structure, can be relevant for future research in the fields of chemistry, biology, medicine, and cosmeceuticals.https://www.mdpi.com/1996-1944/14/12/3217peptidespeptidomimeticscollagenenzyme inhibitorscosmeceuticals |
| spellingShingle | Patrycja Ledwoń Anna Maria Papini Paolo Rovero Rafal Latajka Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation Materials peptides peptidomimetics collagen enzyme inhibitors cosmeceuticals |
| title | Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation |
| title_full | Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation |
| title_fullStr | Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation |
| title_full_unstemmed | Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation |
| title_short | Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation |
| title_sort | peptides and peptidomimetics as inhibitors of enzymes involved in fibrillar collagen degradation |
| topic | peptides peptidomimetics collagen enzyme inhibitors cosmeceuticals |
| url | https://www.mdpi.com/1996-1944/14/12/3217 |
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