A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo ()
Age at first calving is an important trait for achieving earlier reproductive performance. To detect quantitative trait loci (QTL) for reproductive traits, a genome wide association study was conducted on the 96 Hanwoo cows that were born between 2008 and 2010 from 13 sires in a local farm (Juk-Am H...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Asian-Australasian Association of Animal Production Societies
2014-10-01
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| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/ajas-27-10-1406.pdf |
| _version_ | 1819089256699658240 |
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| author | K.-E. Hyeong A. Iqbal J.-J. Kim |
| author_facet | K.-E. Hyeong A. Iqbal J.-J. Kim |
| author_sort | K.-E. Hyeong |
| collection | DOAJ |
| description | Age at first calving is an important trait for achieving earlier reproductive performance. To detect quantitative trait loci (QTL) for reproductive traits, a genome wide association study was conducted on the 96 Hanwoo cows that were born between 2008 and 2010 from 13 sires in a local farm (Juk-Am Hanwoo farm, Suncheon, Korea) and genotyped with the Illumina 50K bovine single nucleotide polymorphism (SNP) chips. Phenotypes were regressed on additive and dominance effects for each SNP using a simple linear regression model after the effects of birth-year-month and polygenes were considered. A forward regression procedure was applied to determine the best set of SNPs for age at first calving. A total of 15 QTL were detected at the comparison-wise 0.001 level. Two QTL with strong statistical evidence were found at 128.9 Mb and 111.1 Mb on bovine chromosomes (BTA) 2 and 7, respectively, each of which accounted for 22% of the phenotypic variance. Also, five significant SNPs were detected on BTAs 10, 16, 20, 26, and 29. Multiple QTL were found on BTAs 1, 2, 7, and 14. The significant QTLs may be applied via marker assisted selection to increase rate of genetic gain for the trait, after validation tests in other Hanwoo cow populations. |
| first_indexed | 2024-12-21T22:05:03Z |
| format | Article |
| id | doaj.art-942478627d40454bb61e1482534d0cc3 |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-12-21T22:05:03Z |
| publishDate | 2014-10-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-942478627d40454bb61e1482534d0cc32022-12-21T18:48:44ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172014-10-0127101406141010.5713/ajas.2014.1427322941A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo ()K.-E. HyeongA. IqbalJ.-J. KimAge at first calving is an important trait for achieving earlier reproductive performance. To detect quantitative trait loci (QTL) for reproductive traits, a genome wide association study was conducted on the 96 Hanwoo cows that were born between 2008 and 2010 from 13 sires in a local farm (Juk-Am Hanwoo farm, Suncheon, Korea) and genotyped with the Illumina 50K bovine single nucleotide polymorphism (SNP) chips. Phenotypes were regressed on additive and dominance effects for each SNP using a simple linear regression model after the effects of birth-year-month and polygenes were considered. A forward regression procedure was applied to determine the best set of SNPs for age at first calving. A total of 15 QTL were detected at the comparison-wise 0.001 level. Two QTL with strong statistical evidence were found at 128.9 Mb and 111.1 Mb on bovine chromosomes (BTA) 2 and 7, respectively, each of which accounted for 22% of the phenotypic variance. Also, five significant SNPs were detected on BTAs 10, 16, 20, 26, and 29. Multiple QTL were found on BTAs 1, 2, 7, and 14. The significant QTLs may be applied via marker assisted selection to increase rate of genetic gain for the trait, after validation tests in other Hanwoo cow populations.http://www.ajas.info/upload/pdf/ajas-27-10-1406.pdfFirst CalvingHanwooQuantitative Trait Loci [QTL]Single Nucleotide Polymorphism [SNP]Whole Genome Association [WGA] |
| spellingShingle | K.-E. Hyeong A. Iqbal J.-J. Kim A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () Asian-Australasian Journal of Animal Sciences First Calving Hanwoo Quantitative Trait Loci [QTL] Single Nucleotide Polymorphism [SNP] Whole Genome Association [WGA] |
| title | A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () |
| title_full | A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () |
| title_fullStr | A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () |
| title_full_unstemmed | A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () |
| title_short | A Genome Wide Association Study on Age at First Calving Using High Density Single Nucleotide Polymorphism Chips in Hanwoo () |
| title_sort | genome wide association study on age at first calving using high density single nucleotide polymorphism chips in hanwoo |
| topic | First Calving Hanwoo Quantitative Trait Loci [QTL] Single Nucleotide Polymorphism [SNP] Whole Genome Association [WGA] |
| url | http://www.ajas.info/upload/pdf/ajas-27-10-1406.pdf |
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