Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque
A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO<sub>2</sub> nanocarriers (SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>-NH<sub>2</sub>NPs), which may potentially...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/260 |
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| author | Yuriy Gerasymchuk Wojciech Kałas Jacek Arkowski Łukasz Marciniak Dariusz Hreniak Edyta Wysokińska Leon Strządała Marta Obremska Larysa Tomachynski Viktor Chernii Wiesław Stręk |
| author_facet | Yuriy Gerasymchuk Wojciech Kałas Jacek Arkowski Łukasz Marciniak Dariusz Hreniak Edyta Wysokińska Leon Strządała Marta Obremska Larysa Tomachynski Viktor Chernii Wiesław Stręk |
| author_sort | Yuriy Gerasymchuk |
| collection | DOAJ |
| description | A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO<sub>2</sub> nanocarriers (SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>-NH<sub>2</sub>NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO<sub>2</sub> conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO<sub>2</sub> as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease. |
| first_indexed | 2024-03-09T05:53:22Z |
| format | Article |
| id | doaj.art-94247a73a38d47c7b0875802854badfe |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:53:22Z |
| publishDate | 2021-01-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-94247a73a38d47c7b0875802854badfe2023-12-03T12:15:57ZengMDPI AGMolecules1420-30492021-01-0126226010.3390/molecules26020260Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic PlaqueYuriy Gerasymchuk0Wojciech Kałas1Jacek Arkowski2Łukasz Marciniak3Dariusz Hreniak4Edyta Wysokińska5Leon Strządała6Marta Obremska7Larysa Tomachynski8Viktor Chernii9Wiesław Stręk10Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, PolandLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Preclinical Studies, Wrocław Medical University, ul. K. Bartla 5, 51-618 Wrocław, PolandInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, PolandInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, PolandLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, PolandLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Preclinical Studies, Wrocław Medical University, ul. K. Bartla 5, 51-618 Wrocław, PolandV.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., 03-142 Kyiv, UkraineV.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., 03-142 Kyiv, UkraineInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, PolandA new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO<sub>2</sub> nanocarriers (SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>-NH<sub>2</sub>NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO<sub>2</sub> conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO<sub>2</sub> as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease.https://www.mdpi.com/1420-3049/26/2/260axially substitutedwater solublezirconium phthalocyaninesSiO<sub>2</sub> nanocarriersphotosensitizersROS generation |
| spellingShingle | Yuriy Gerasymchuk Wojciech Kałas Jacek Arkowski Łukasz Marciniak Dariusz Hreniak Edyta Wysokińska Leon Strządała Marta Obremska Larysa Tomachynski Viktor Chernii Wiesław Stręk Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque Molecules axially substituted water soluble zirconium phthalocyanines SiO<sub>2</sub> nanocarriers photosensitizers ROS generation |
| title | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
| title_full | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
| title_fullStr | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
| title_full_unstemmed | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
| title_short | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
| title_sort | gallato zirconium iv phtalocyanine complex conjugated with sio sub 2 sub nanocarrier as a photoactive drug for photodynamic therapy of atheromatic plaque |
| topic | axially substituted water soluble zirconium phthalocyanines SiO<sub>2</sub> nanocarriers photosensitizers ROS generation |
| url | https://www.mdpi.com/1420-3049/26/2/260 |
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