Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique
In the present research the development of liposomes by studying various processes as well as formulation related factors such as effect of cholesterol, effect of alkyl chain length of lipids which may affect the size, shape and encapsulation efficiency of liposomes was reported. Cholesterol and pho...
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| Format: | Article |
| Language: | English |
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Unviversity of Technology- Iraq
2014-03-01
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| Series: | Engineering and Technology Journal |
| Subjects: | |
| Online Access: | https://etj.uotechnology.edu.iq/article_102473_1d84a15664a3004327c0ae83c08ed9ca.pdf |
| _version_ | 1797325730515779584 |
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| author | labeeb Ahmed Al-Zubaidi Mahdi Salih Al-Rubaie Tagreed Sabeah Abdullah |
| author_facet | labeeb Ahmed Al-Zubaidi Mahdi Salih Al-Rubaie Tagreed Sabeah Abdullah |
| author_sort | labeeb Ahmed Al-Zubaidi |
| collection | DOAJ |
| description | In the present research the development of liposomes by studying various processes as well as formulation related factors such as effect of cholesterol, effect of alkyl chain length of lipids which may affect the size, shape and encapsulation efficiency of liposomes was reported. Cholesterol and phospholipids were studied by Fourier transform infrared (FTIR) spectroscopy. From scanning electron micrographs, the liposomes appeared in various figures, the sizes of prepared liposomal particles varied in the range of 0.147-0.412 um (147- 412) nm and most of them were multilamellar structures. The vesicle size was found to be varied from 0.147 to 0.412 um. The liposomes were photographed using scanning electron microscope. Vesicles were found to be spherical in shape. Analysis of vesicle size was carried out of each formulation code and the size was found to be reproducible. FT-IR is very useful tool for detecting chemical changes, chemical structures and the thermodynamic of phase transitions and conformational changes in biological systems. Frequency shifts in different regions (symmetric, anti-symmetric stretching or bending, scissoring) or changes in the widths of the corresponding peaks can be used to extract information about various physicochemical processes taking place preparation. This research review the development of liposomes, and speculates optimistically about some future applications. |
| first_indexed | 2024-03-08T06:13:38Z |
| format | Article |
| id | doaj.art-9424b59f7ce9476997908782325a7442 |
| institution | Directory Open Access Journal |
| issn | 1681-6900 2412-0758 |
| language | English |
| last_indexed | 2024-03-08T06:13:38Z |
| publishDate | 2014-03-01 |
| publisher | Unviversity of Technology- Iraq |
| record_format | Article |
| series | Engineering and Technology Journal |
| spelling | doaj.art-9424b59f7ce9476997908782325a74422024-02-04T17:30:14ZengUnviversity of Technology- IraqEngineering and Technology Journal1681-69002412-07582014-03-01323B55056010.30684/etj.32.3B.16102473Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Techniquelabeeb Ahmed Al-ZubaidiMahdi Salih Al-RubaieTagreed Sabeah AbdullahIn the present research the development of liposomes by studying various processes as well as formulation related factors such as effect of cholesterol, effect of alkyl chain length of lipids which may affect the size, shape and encapsulation efficiency of liposomes was reported. Cholesterol and phospholipids were studied by Fourier transform infrared (FTIR) spectroscopy. From scanning electron micrographs, the liposomes appeared in various figures, the sizes of prepared liposomal particles varied in the range of 0.147-0.412 um (147- 412) nm and most of them were multilamellar structures. The vesicle size was found to be varied from 0.147 to 0.412 um. The liposomes were photographed using scanning electron microscope. Vesicles were found to be spherical in shape. Analysis of vesicle size was carried out of each formulation code and the size was found to be reproducible. FT-IR is very useful tool for detecting chemical changes, chemical structures and the thermodynamic of phase transitions and conformational changes in biological systems. Frequency shifts in different regions (symmetric, anti-symmetric stretching or bending, scissoring) or changes in the widths of the corresponding peaks can be used to extract information about various physicochemical processes taking place preparation. This research review the development of liposomes, and speculates optimistically about some future applications.https://etj.uotechnology.edu.iq/article_102473_1d84a15664a3004327c0ae83c08ed9ca.pdfmulti lamellar vesiclesliposomesthin film hydration |
| spellingShingle | labeeb Ahmed Al-Zubaidi Mahdi Salih Al-Rubaie Tagreed Sabeah Abdullah Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique Engineering and Technology Journal multi lamellar vesicles liposomes thin film hydration |
| title | Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique |
| title_full | Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique |
| title_fullStr | Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique |
| title_full_unstemmed | Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique |
| title_short | Multi Lamellar Vesicles (Mlvs) Liposomes Preparation byThin Film Hydration Technique |
| title_sort | multi lamellar vesicles mlvs liposomes preparation bythin film hydration technique |
| topic | multi lamellar vesicles liposomes thin film hydration |
| url | https://etj.uotechnology.edu.iq/article_102473_1d84a15664a3004327c0ae83c08ed9ca.pdf |
| work_keys_str_mv | AT labeebahmedalzubaidi multilamellarvesiclesmlvsliposomespreparationbythinfilmhydrationtechnique AT mahdisalihalrubaie multilamellarvesiclesmlvsliposomespreparationbythinfilmhydrationtechnique AT tagreedsabeahabdullah multilamellarvesiclesmlvsliposomespreparationbythinfilmhydrationtechnique |