The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
Abstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified th...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-05764-5 |
| _version_ | 1818343782444171264 |
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| author | Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer |
| author_facet | Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer |
| author_sort | Kornelius Kupczik |
| collection | DOAJ |
| description | Abstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors. In addition, the deciduous fourth premolars and permanent first and second molars consistently lacked the distal and lingual cusps; this resulted in only a single enlarged cusp in the basin-like heel (talonid in lower molars, talon in upper molars). This molar phenotype is also found among several living and fossil carnivorans and the extinct order Creodonta in which it is associated with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in dental (cusp) development within and across mammalian lineages including the hominids which are known to exhibit marked variability in the presence of lingual cusps. |
| first_indexed | 2024-12-13T16:36:03Z |
| format | Article |
| id | doaj.art-94261aecac0f47f6ac00b8280aefedaa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T16:36:03Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-94261aecac0f47f6ac00b8280aefedaa2022-12-21T23:38:24ZengNature PortfolioScientific Reports2045-23222017-07-01711810.1038/s41598-017-05764-5The dental phenotype of hairless dogs with FOXI3 haploinsufficiencyKornelius Kupczik0Alexander Cagan1Silke Brauer2Martin S. Fischer3Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary AnthropologyDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary AnthropologyMax Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary AnthropologyInstitut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich-Schiller-UniversitätAbstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors. In addition, the deciduous fourth premolars and permanent first and second molars consistently lacked the distal and lingual cusps; this resulted in only a single enlarged cusp in the basin-like heel (talonid in lower molars, talon in upper molars). This molar phenotype is also found among several living and fossil carnivorans and the extinct order Creodonta in which it is associated with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in dental (cusp) development within and across mammalian lineages including the hominids which are known to exhibit marked variability in the presence of lingual cusps.https://doi.org/10.1038/s41598-017-05764-5 |
| spellingShingle | Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer The dental phenotype of hairless dogs with FOXI3 haploinsufficiency Scientific Reports |
| title | The dental phenotype of hairless dogs with FOXI3 haploinsufficiency |
| title_full | The dental phenotype of hairless dogs with FOXI3 haploinsufficiency |
| title_fullStr | The dental phenotype of hairless dogs with FOXI3 haploinsufficiency |
| title_full_unstemmed | The dental phenotype of hairless dogs with FOXI3 haploinsufficiency |
| title_short | The dental phenotype of hairless dogs with FOXI3 haploinsufficiency |
| title_sort | dental phenotype of hairless dogs with foxi3 haploinsufficiency |
| url | https://doi.org/10.1038/s41598-017-05764-5 |
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