The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites

The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites

Mitochondria-associated ER membranes (MAMs) are crucial for lipid transport and synthesis, calcium exchange, and mitochondrial functions, and they also act as signaling platforms. These contact sites also play a critical role in the decision between autophagy and apoptosis with far reaching implicat...

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Bibliographic Details
Main Authors: Manon Moulis, Elisa Grousset, Julien Faccini, Kevin Richetin, Gary Thomas, Cecile Vindis
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
PACS-2
mitochondria-associated ER membranes (MAMs)
mitochondria
mitophagy
apoptosis
atherosclerosis
vascular smooth muscle cell
Online Access:https://www.mdpi.com/2073-4409/8/6/638

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