Functional state of kidneys in patients with clinical manifestations of hypothyroidism
The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The cl...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Saratov State Medical University
2012-06-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/201202_333-338.pdf |
| _version_ | 1818741171159040000 |
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| author | Rodionova T.I. Orlova М.М. |
| author_facet | Rodionova T.I. Orlova М.М. |
| author_sort | Rodionova T.I. |
| collection | DOAJ |
| description | The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results: The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentra-tional kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion: It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression |
| first_indexed | 2024-12-18T01:52:23Z |
| format | Article |
| id | doaj.art-94288ffae40b48e7bf19253e7bf75842 |
| institution | Directory Open Access Journal |
| issn | 1995-0039 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-18T01:52:23Z |
| publishDate | 2012-06-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-94288ffae40b48e7bf19253e7bf758422022-12-21T21:24:59ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182012-06-0182333338Functional state of kidneys in patients with clinical manifestations of hypothyroidismRodionova T.I.Orlova М.М.The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results: The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentra-tional kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion: It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progressionhttp://www.ssmj.ru/system/files/201202_333-338.pdfrenal functionspeed of glomerular filtrationthyroid hormones |
| spellingShingle | Rodionova T.I. Orlova М.М. Functional state of kidneys in patients with clinical manifestations of hypothyroidism Саратовский научно-медицинский журнал renal function speed of glomerular filtration thyroid hormones |
| title | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_full | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_fullStr | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_full_unstemmed | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_short | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_sort | functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| topic | renal function speed of glomerular filtration thyroid hormones |
| url | http://www.ssmj.ru/system/files/201202_333-338.pdf |
| work_keys_str_mv | AT rodionovati functionalstateofkidneysinpatientswithclinicalmanifestationsofhypothyroidism AT orlovamm functionalstateofkidneysinpatientswithclinicalmanifestationsofhypothyroidism |