Overcoming the therapeutic resistance of hepatomas by targeting the tumor microenvironment

Overcoming the therapeutic resistance of hepatomas by targeting the tumor microenvironment

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is the third leading cause of cancer-related mortality worldwide. Multifactorial drug resistance is regarded as the major cause of treatment failure in HCC. Accumulating evidence shows that the constituents of the...

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Bibliographic Details
Main Authors: Jiaxin Zhang, Huiqiong Han, Lei Wang, Wenjia Wang, Mei Yang, Yanru Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
tumor microenvironment
therapeutic resistance
therapeutic targets
novel drugs
patient-derived organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.988956/full

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