Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration
Central nervous system (CNS) damage leads to severe neurological dysfunction as a result of neuronal cell death and axonal degeneration. As, in the mature CNS, neurons have little ability to regenerate their axons and reconstruct neural loss, demyelination is one of the hallmarks of neurological dis...
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MDPI AG
2024-03-01
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author | Magdalena Namiecinska Paweł Piatek Przemysław Lewkowicz |
author_facet | Magdalena Namiecinska Paweł Piatek Przemysław Lewkowicz |
author_sort | Magdalena Namiecinska |
collection | DOAJ |
description | Central nervous system (CNS) damage leads to severe neurological dysfunction as a result of neuronal cell death and axonal degeneration. As, in the mature CNS, neurons have little ability to regenerate their axons and reconstruct neural loss, demyelination is one of the hallmarks of neurological disorders such as multiple sclerosis (MS). Unfortunately, remyelination, as a regenerative process, is often insufficient to prevent axonal loss and improve neurological deficits after demyelination. Currently, there are still no effective therapeutic tools to restore neurological function, but interestingly, emerging studies prove the beneficial effects of lipid supplementation in a wide variety of pathological processes in the human body. In the future, available lipids with a proven beneficial effect on CNS regeneration could be included in supportive therapy, but this topic still requires further studies. Based on our and others’ research, we review the role of exogenous lipids, pointing to substrates that are crucial in the remyelination process but are omitted in available studies, justifying the properly profiled supply of lipids in the human diet as a supportive therapy during CNS regeneration. |
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last_indexed | 2024-04-24T10:43:31Z |
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spelling | doaj.art-942a845b3ec44d19b95a1a7ccdcbb65d2024-04-12T13:19:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01257379210.3390/ijms25073792Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System RegenerationMagdalena Namiecinska0Paweł Piatek1Przemysław Lewkowicz2Department of Immunogenetics, Medical University of Lodz, Pomorska 251/A4 Street, 92-213 Lodz, PolandDepartment of Immunogenetics, Medical University of Lodz, Pomorska 251/A4 Street, 92-213 Lodz, PolandDepartment of Immunogenetics, Medical University of Lodz, Pomorska 251/A4 Street, 92-213 Lodz, PolandCentral nervous system (CNS) damage leads to severe neurological dysfunction as a result of neuronal cell death and axonal degeneration. As, in the mature CNS, neurons have little ability to regenerate their axons and reconstruct neural loss, demyelination is one of the hallmarks of neurological disorders such as multiple sclerosis (MS). Unfortunately, remyelination, as a regenerative process, is often insufficient to prevent axonal loss and improve neurological deficits after demyelination. Currently, there are still no effective therapeutic tools to restore neurological function, but interestingly, emerging studies prove the beneficial effects of lipid supplementation in a wide variety of pathological processes in the human body. In the future, available lipids with a proven beneficial effect on CNS regeneration could be included in supportive therapy, but this topic still requires further studies. Based on our and others’ research, we review the role of exogenous lipids, pointing to substrates that are crucial in the remyelination process but are omitted in available studies, justifying the properly profiled supply of lipids in the human diet as a supportive therapy during CNS regeneration.https://www.mdpi.com/1422-0067/25/7/3792nervonic acidPUFAsnatural fish oilneurodegenerative diseasesremyelinationCNS regeneration |
spellingShingle | Magdalena Namiecinska Paweł Piatek Przemysław Lewkowicz Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration International Journal of Molecular Sciences nervonic acid PUFAs natural fish oil neurodegenerative diseases remyelination CNS regeneration |
title | Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration |
title_full | Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration |
title_fullStr | Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration |
title_full_unstemmed | Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration |
title_short | Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration |
title_sort | nervonic acid synthesis substrates as essential components in profiled lipid supplementation for more effective central nervous system regeneration |
topic | nervonic acid PUFAs natural fish oil neurodegenerative diseases remyelination CNS regeneration |
url | https://www.mdpi.com/1422-0067/25/7/3792 |
work_keys_str_mv | AT magdalenanamiecinska nervonicacidsynthesissubstratesasessentialcomponentsinprofiledlipidsupplementationformoreeffectivecentralnervoussystemregeneration AT pawełpiatek nervonicacidsynthesissubstratesasessentialcomponentsinprofiledlipidsupplementationformoreeffectivecentralnervoussystemregeneration AT przemysławlewkowicz nervonicacidsynthesissubstratesasessentialcomponentsinprofiledlipidsupplementationformoreeffectivecentralnervoussystemregeneration |