La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale
In spite of findings of large-scale clinical trials which showed an overall reduction of morbidity and mortality from coronary heart disease in patients treated with 3-hydroxy-3-metylglutaryl coenzyme-A reductase inhibitors (statins), relatively little is still known about the real prevalence of tre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SEEd Medical Publishers
2003-05-01
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| Series: | Farmeconomia: Health Economics and Therapeutic Pathways |
| Online Access: | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/1033 |
| _version_ | 1811268495584788480 |
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| author | Mirko Di Martino Alessandro Capone Pierluigi Russo Luca Degli Esposti Pierluigi Ceccarelli Stefano Buda Ezio Degli Esposti Luciano Caprino |
| author_facet | Mirko Di Martino Alessandro Capone Pierluigi Russo Luca Degli Esposti Pierluigi Ceccarelli Stefano Buda Ezio Degli Esposti Luciano Caprino |
| author_sort | Mirko Di Martino |
| collection | DOAJ |
| description | In spite of findings of large-scale clinical trials which showed an overall reduction of morbidity and mortality from coronary heart disease in patients treated with 3-hydroxy-3-metylglutaryl coenzyme-A reductase inhibitors (statins), relatively little is still known about the real prevalence of treatment in general practice setting, particularly in patients with a high cardiovascular risk. The objective of this study was to investigate among patients with cardiovascular risk profile estimated according to the Framingham Heart Prediction Risk Study, the percentage of those exposed to statins, and the proportion of patients reaching total cholesterol (TC) target levels. A cross-sectional analysis was conducted on a large cohort of patients listed in the administrative databases of the Local Health Unit of Ravenna (total resident population of 356,000). In 2001, every single patient who received a prescription for a statin, and/or with a recorded plasma TC level, and/or with a hospital admission for cardiovascular reasons (identified by ICD-9 code), and/or with a clinical appraisal based on the presence of cardiovascular risk factors, was defined eligible. Sebsequently, pharmaceutical, and nosocomial databases, were cross-linked with that of 50 general practitioners in order to assess the pharmacoutilization of statins on a patient-by-patient basis. A cohort of 9,208 patients with a well documented cardiovascular risk profile were analyzed. The mean age of those patients was 57 (SD=17) years and 42% of them was male. On the basis of raised TC levels and cardiovascular risk profiles, patients for whom a statin treatment was suggested amounted to 7,233. However, the number of those who received statins was significantly lower (n = 1,343), corresponding to 18.6%. In those exposed to statins, just a small group of patients reached a level of TC below 190 mg/dl (n = 271), equivalent to 20.2%. In the group of treated who did not achieve recommended TC target levels, 31.7% (n = 340) of patients was at very high cardiovascular risk. Moreover, among all patients with high plasma TC levels (n=5,890), there was a 45.7% (n = 2,690) who did not received any lipid lowering drug even though they had a high cardiovascular risk profile. Results from large population-based administrative databases suggest a remarkable level of undertreatment among patients with cardiovascular risk factors. Furthermore, many patients did not achieve recommended TC target levels with their statin treatment. Pharmacoutilization of statins in general practice reveals the need of a more careful pursuing of therapeutic goals. |
| first_indexed | 2024-04-12T21:22:37Z |
| format | Article |
| id | doaj.art-942b343c131545b8ae03cf589a71a6a5 |
| institution | Directory Open Access Journal |
| issn | 2240-256X |
| language | English |
| last_indexed | 2024-04-12T21:22:37Z |
| publishDate | 2003-05-01 |
| publisher | SEEd Medical Publishers |
| record_format | Article |
| series | Farmeconomia: Health Economics and Therapeutic Pathways |
| spelling | doaj.art-942b343c131545b8ae03cf589a71a6a52022-12-22T03:16:15ZengSEEd Medical PublishersFarmeconomia: Health Economics and Therapeutic Pathways2240-256X2003-05-0141S152310.7175/fe.v4i1S.1033969La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generaleMirko Di Martino0Alessandro Capone1Pierluigi Russo2Luca Degli Esposti3Pierluigi Ceccarelli4Stefano Buda5Ezio Degli Esposti6Luciano Caprino7CliCon Srl - Health, Economics, and Outcomes Research, RavennaCliCon Srl - Health, Economics, and Outcomes Research, RavennaDipartimento di Fisiologia Umana e Farmacologia, Università “La Sapienza”, RomaCliCon Srl - Health, Economics, and Outcomes Research, RavennaCliCon Srl - Health, Economics, and Outcomes Research, RavennaCliCon Srl - Health, Economics, and Outcomes Research, RavennaUnità di Valutazione dell’Efficacia Clinica, AUSL 110 di RavennaDipartimento di Fisiologia Umana e Farmacologia, Università “La Sapienza”, RomaIn spite of findings of large-scale clinical trials which showed an overall reduction of morbidity and mortality from coronary heart disease in patients treated with 3-hydroxy-3-metylglutaryl coenzyme-A reductase inhibitors (statins), relatively little is still known about the real prevalence of treatment in general practice setting, particularly in patients with a high cardiovascular risk. The objective of this study was to investigate among patients with cardiovascular risk profile estimated according to the Framingham Heart Prediction Risk Study, the percentage of those exposed to statins, and the proportion of patients reaching total cholesterol (TC) target levels. A cross-sectional analysis was conducted on a large cohort of patients listed in the administrative databases of the Local Health Unit of Ravenna (total resident population of 356,000). In 2001, every single patient who received a prescription for a statin, and/or with a recorded plasma TC level, and/or with a hospital admission for cardiovascular reasons (identified by ICD-9 code), and/or with a clinical appraisal based on the presence of cardiovascular risk factors, was defined eligible. Sebsequently, pharmaceutical, and nosocomial databases, were cross-linked with that of 50 general practitioners in order to assess the pharmacoutilization of statins on a patient-by-patient basis. A cohort of 9,208 patients with a well documented cardiovascular risk profile were analyzed. The mean age of those patients was 57 (SD=17) years and 42% of them was male. On the basis of raised TC levels and cardiovascular risk profiles, patients for whom a statin treatment was suggested amounted to 7,233. However, the number of those who received statins was significantly lower (n = 1,343), corresponding to 18.6%. In those exposed to statins, just a small group of patients reached a level of TC below 190 mg/dl (n = 271), equivalent to 20.2%. In the group of treated who did not achieve recommended TC target levels, 31.7% (n = 340) of patients was at very high cardiovascular risk. Moreover, among all patients with high plasma TC levels (n=5,890), there was a 45.7% (n = 2,690) who did not received any lipid lowering drug even though they had a high cardiovascular risk profile. Results from large population-based administrative databases suggest a remarkable level of undertreatment among patients with cardiovascular risk factors. Furthermore, many patients did not achieve recommended TC target levels with their statin treatment. Pharmacoutilization of statins in general practice reveals the need of a more careful pursuing of therapeutic goals.https://journals.seedmedicalpublishers.com/index.php/FE/article/view/1033 |
| spellingShingle | Mirko Di Martino Alessandro Capone Pierluigi Russo Luca Degli Esposti Pierluigi Ceccarelli Stefano Buda Ezio Degli Esposti Luciano Caprino La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale Farmeconomia: Health Economics and Therapeutic Pathways |
| title | La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| title_full | La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| title_fullStr | La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| title_full_unstemmed | La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| title_short | La farmacoutilizzazione delle statine nella pratica clinica: risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| title_sort | la farmacoutilizzazione delle statine nella pratica clinica risultati di uno studio di popolazione condotto su database amministrativi e di medici di medicina generale |
| url | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/1033 |
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