Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study
Background and Aim: Aberrant sleep parameters are associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, existing information is inconsistent among studies and involves reverse causation. Therefore, we aimed to investigate the observational associations and causations between...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.792558/full |
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| author | Hong Fan Hong Fan Hong Fan Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Xin Zhang Xin Zhang Xin Zhang Huangbo Yuan Xiaolan Zhao Renjia Zhao Renjia Zhao Renjia Zhao Tingting Shi Tingting Shi Tingting Shi Sheng Wu Sheng Wu Sheng Wu Yiyun Xu Yiyun Xu Yiyun Xu Chen Suo Chen Suo Chen Suo Xingdong Chen Xingdong Chen Xingdong Chen Xingdong Chen Tiejun Zhang Tiejun Zhang Tiejun Zhang |
| author_facet | Hong Fan Hong Fan Hong Fan Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Xin Zhang Xin Zhang Xin Zhang Huangbo Yuan Xiaolan Zhao Renjia Zhao Renjia Zhao Renjia Zhao Tingting Shi Tingting Shi Tingting Shi Sheng Wu Sheng Wu Sheng Wu Yiyun Xu Yiyun Xu Yiyun Xu Chen Suo Chen Suo Chen Suo Xingdong Chen Xingdong Chen Xingdong Chen Xingdong Chen Tiejun Zhang Tiejun Zhang Tiejun Zhang |
| author_sort | Hong Fan |
| collection | DOAJ |
| description | Background and Aim: Aberrant sleep parameters are associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, existing information is inconsistent among studies and involves reverse causation. Therefore, we aimed to investigate the observational associations and causations between sleep traits and NAFLD.Methods: We performed multivariable regression to assess observational associations of seven sleep traits (sleep duration, easiness of getting up in the morning, chronotype, nap during day, snoring, insomnia, and narcolepsy), and NAFLD in the UK Biobank (1,029 NAFLD). The Cox proportional hazards model was applied to derive hazard ratios and 95% confidence intervals (CIs). Furthermore, a bidirectional two-sample Mendelian randomization (MR) approach was used to explore the causal relationships between sleep traits and NAFLD.Results: In the multivariable regression model adjusted for potential confounders, getting up in the morning not at all easy (HR, 1.51; 95% CI, 1.27–1.78) and usually insomnia (HR, 1.46; 95% CI, 1.21–1.75) were associated with the risk of NAFLD. Furthermore, the easiness of getting up in the morning and insomnia showed a dose–response association with NAFLD (Ptrend <0.05). MR analysis found consistent causal effects of NAFLD on easiness of getting up in the morning (OR, 0.995; 95% CI, 0.990–0.999; p = 0.033) and insomnia (OR, 1.006; 95% CI, 1.001–1.011; p = 0.024). These results were robust to weak instrument bias, pleiotropy, and heterogeneity.Conclusions: Findings showed consistent evidence of observational analyses and MR analyses that trouble getting up in the morning and insomnia were associated with an increased risk of NAFLD. Bidirectional MR demonstrated causal effects of NAFLD on sleep traits. |
| first_indexed | 2024-12-12T11:06:00Z |
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| language | English |
| last_indexed | 2024-12-12T11:06:00Z |
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| spelling | doaj.art-942b6e32605a443cb2544b288fb1668d2022-12-22T00:26:24ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-05-011310.3389/fgene.2022.792558792558Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization StudyHong Fan0Hong Fan1Hong Fan2Zhenqiu Liu3Zhenqiu Liu4Zhenqiu Liu5Zhenqiu Liu6Xin Zhang7Xin Zhang8Xin Zhang9Huangbo Yuan10Xiaolan Zhao11Renjia Zhao12Renjia Zhao13Renjia Zhao14Tingting Shi15Tingting Shi16Tingting Shi17Sheng Wu18Sheng Wu19Sheng Wu20Yiyun Xu21Yiyun Xu22Yiyun Xu23Chen Suo24Chen Suo25Chen Suo26Xingdong Chen27Xingdong Chen28Xingdong Chen29Xingdong Chen30Tiejun Zhang31Tiejun Zhang32Tiejun Zhang33Department of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Chronic Diseases Prevention, Taizhou Center for Disease Control and Prevention, Jiangsu, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, ChinaDepartment of Chronic Diseases Prevention, Taizhou Center for Disease Control and Prevention, Jiangsu, ChinaHuman Phenome Institute, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, ChinaKey Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, ChinaBackground and Aim: Aberrant sleep parameters are associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, existing information is inconsistent among studies and involves reverse causation. Therefore, we aimed to investigate the observational associations and causations between sleep traits and NAFLD.Methods: We performed multivariable regression to assess observational associations of seven sleep traits (sleep duration, easiness of getting up in the morning, chronotype, nap during day, snoring, insomnia, and narcolepsy), and NAFLD in the UK Biobank (1,029 NAFLD). The Cox proportional hazards model was applied to derive hazard ratios and 95% confidence intervals (CIs). Furthermore, a bidirectional two-sample Mendelian randomization (MR) approach was used to explore the causal relationships between sleep traits and NAFLD.Results: In the multivariable regression model adjusted for potential confounders, getting up in the morning not at all easy (HR, 1.51; 95% CI, 1.27–1.78) and usually insomnia (HR, 1.46; 95% CI, 1.21–1.75) were associated with the risk of NAFLD. Furthermore, the easiness of getting up in the morning and insomnia showed a dose–response association with NAFLD (Ptrend <0.05). MR analysis found consistent causal effects of NAFLD on easiness of getting up in the morning (OR, 0.995; 95% CI, 0.990–0.999; p = 0.033) and insomnia (OR, 1.006; 95% CI, 1.001–1.011; p = 0.024). These results were robust to weak instrument bias, pleiotropy, and heterogeneity.Conclusions: Findings showed consistent evidence of observational analyses and MR analyses that trouble getting up in the morning and insomnia were associated with an increased risk of NAFLD. Bidirectional MR demonstrated causal effects of NAFLD on sleep traits.https://www.frontiersin.org/articles/10.3389/fgene.2022.792558/fullMendelian randomizationnonalcoholic fatty liver diseasesleep durationinsomniaeasiness of getting up in the morning |
| spellingShingle | Hong Fan Hong Fan Hong Fan Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Zhenqiu Liu Xin Zhang Xin Zhang Xin Zhang Huangbo Yuan Xiaolan Zhao Renjia Zhao Renjia Zhao Renjia Zhao Tingting Shi Tingting Shi Tingting Shi Sheng Wu Sheng Wu Sheng Wu Yiyun Xu Yiyun Xu Yiyun Xu Chen Suo Chen Suo Chen Suo Xingdong Chen Xingdong Chen Xingdong Chen Xingdong Chen Tiejun Zhang Tiejun Zhang Tiejun Zhang Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study Frontiers in Genetics Mendelian randomization nonalcoholic fatty liver disease sleep duration insomnia easiness of getting up in the morning |
| title | Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study |
| title_full | Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study |
| title_fullStr | Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study |
| title_full_unstemmed | Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study |
| title_short | Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study |
| title_sort | investigating the association between seven sleep traits and nonalcoholic fatty liver disease observational and mendelian randomization study |
| topic | Mendelian randomization nonalcoholic fatty liver disease sleep duration insomnia easiness of getting up in the morning |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.792558/full |
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