Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center
Abstract Objective To explore the histopathological characteristics of paired recurrent gliomas and their clinical significance. Methods Glioma patients who received both primary surgery and reoperation when recurrence at Sun Yat-sen University Cancer Center from June 2001 to June 2019 were enrolled...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10484-9 |
| _version_ | 1797958658804416512 |
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| author | Cong Li Shaoyan Xi Yingshen Chen Chengcheng Guo Ji Zhang Qunying Yang Jian Wang Ke Sai Jing Zeng Jing Wang Zhiqiang Zhang Chao Ke Zhongping Chen |
| author_facet | Cong Li Shaoyan Xi Yingshen Chen Chengcheng Guo Ji Zhang Qunying Yang Jian Wang Ke Sai Jing Zeng Jing Wang Zhiqiang Zhang Chao Ke Zhongping Chen |
| author_sort | Cong Li |
| collection | DOAJ |
| description | Abstract Objective To explore the histopathological characteristics of paired recurrent gliomas and their clinical significance. Methods Glioma patients who received both primary surgery and reoperation when recurrence at Sun Yat-sen University Cancer Center from June 2001 to June 2019 were enrolled. Clinical and pathological characteristics were analyzed retrospectively, and histopathology of reoperation specimens was divided into three categories according to tumor cell activity and the degree of necrosis: active group, low-activity group, and necrosis group. Results A total of 89 patients were included in this study. The 2016 WHO grade of the first operation pathology and IDH1 status were related to survival time after the first operation, but there was no significant association with survival time after reoperation. The time interval between primary and reoperation was shorter for primary high-grade glioma and/or IDH1 wild-type tumor patients than for low-grade glioma and/or IDH1 mutant tumor patients (P < 0.001). Histopathological types of recurrent gliomas were analyzed, and 67 cases (75.3%) were classified into the active group, 14 (15.8%) into the low-activity group, and 8 (8.9%) into the necrosis group. The low-activity or necrosis group was associated with a higher radiotherapy dose and shorter operation interval. Further univariate and multivariate Cox survival analyses showed the histopathological patterns of recurrent gliomas to be related to survival time after reoperation. Conclusion Primary WHO low grade or IDH1 mutant gliomas appeared survival benefit mainly on later recurrence, but was not a prognostic predictor following recurrence. Histopathological feature of recurrent glioma is related to previous treatment, including radiotherapy dosage and chemotherapy treatment, and is also an important independent prognostic factor for patients after reoperation. |
| first_indexed | 2024-04-11T00:22:06Z |
| format | Article |
| id | doaj.art-942e238531d340e48c84b2164991dd02 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T00:22:06Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-942e238531d340e48c84b2164991dd022023-01-08T12:14:14ZengBMCBMC Cancer1471-24072023-01-012311910.1186/s12885-022-10484-9Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer centerCong Li0Shaoyan Xi1Yingshen Chen2Chengcheng Guo3Ji Zhang4Qunying Yang5Jian Wang6Ke Sai7Jing Zeng8Jing Wang9Zhiqiang Zhang10Chao Ke11Zhongping Chen12State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese MedicineState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterAbstract Objective To explore the histopathological characteristics of paired recurrent gliomas and their clinical significance. Methods Glioma patients who received both primary surgery and reoperation when recurrence at Sun Yat-sen University Cancer Center from June 2001 to June 2019 were enrolled. Clinical and pathological characteristics were analyzed retrospectively, and histopathology of reoperation specimens was divided into three categories according to tumor cell activity and the degree of necrosis: active group, low-activity group, and necrosis group. Results A total of 89 patients were included in this study. The 2016 WHO grade of the first operation pathology and IDH1 status were related to survival time after the first operation, but there was no significant association with survival time after reoperation. The time interval between primary and reoperation was shorter for primary high-grade glioma and/or IDH1 wild-type tumor patients than for low-grade glioma and/or IDH1 mutant tumor patients (P < 0.001). Histopathological types of recurrent gliomas were analyzed, and 67 cases (75.3%) were classified into the active group, 14 (15.8%) into the low-activity group, and 8 (8.9%) into the necrosis group. The low-activity or necrosis group was associated with a higher radiotherapy dose and shorter operation interval. Further univariate and multivariate Cox survival analyses showed the histopathological patterns of recurrent gliomas to be related to survival time after reoperation. Conclusion Primary WHO low grade or IDH1 mutant gliomas appeared survival benefit mainly on later recurrence, but was not a prognostic predictor following recurrence. Histopathological feature of recurrent glioma is related to previous treatment, including radiotherapy dosage and chemotherapy treatment, and is also an important independent prognostic factor for patients after reoperation.https://doi.org/10.1186/s12885-022-10484-9Recurrent gliomaReoperationHistopathologyPrognosis |
| spellingShingle | Cong Li Shaoyan Xi Yingshen Chen Chengcheng Guo Ji Zhang Qunying Yang Jian Wang Ke Sai Jing Zeng Jing Wang Zhiqiang Zhang Chao Ke Zhongping Chen Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center BMC Cancer Recurrent glioma Reoperation Histopathology Prognosis |
| title | Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center |
| title_full | Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center |
| title_fullStr | Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center |
| title_full_unstemmed | Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center |
| title_short | Clinical significance of histopathological features of paired recurrent gliomas: a cohort study from a single cancer center |
| title_sort | clinical significance of histopathological features of paired recurrent gliomas a cohort study from a single cancer center |
| topic | Recurrent glioma Reoperation Histopathology Prognosis |
| url | https://doi.org/10.1186/s12885-022-10484-9 |
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