In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers
Purpose: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI‐1), P-Selectin, Tissue Inhibitors Metal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-09-01
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| Series: | Blood Pressure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08037051.2018.1461010 |
| _version_ | 1827817841181589504 |
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| author | Alessandro Maloberti Francesca Farina Marco Carbonaro Enrico Piccinelli Ilaria Bassi Francesco Pansera Guido Grassi Giuseppe Mancia Paola Palestini Cristina Giannattasio |
| author_facet | Alessandro Maloberti Francesca Farina Marco Carbonaro Enrico Piccinelli Ilaria Bassi Francesco Pansera Guido Grassi Giuseppe Mancia Paola Palestini Cristina Giannattasio |
| author_sort | Alessandro Maloberti |
| collection | DOAJ |
| description | Purpose: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI‐1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases. Materials and Methods: 480 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Hypertrophy (LVH) and Intima Media Thickness (IMT) and carotid plaque presence) grouped together under carotid TOD. Results: 3.1% of the subjects showed a PWV higher than 10 m/sec with those subjects exerting significantly lower values of P-Selectine (0.068 ± 0.015 vs 0.08 ± 0.036 mg/L, p = .014). 8.8% of the subjects showed carotid TOD that was associated with higher Cystatin-C values (0.67 ± 0.17 vs 0.63 ± 0.14 mg/L, p = .045). Finally 23.8% of the subjects showed LVH with no significant differences regarding biomarkers. Despite some significant correlations between biomarkers and TOD, at the multivariate analysis none came out to be as significant predictor of the assessed TOD. Conclusions: in normotensive and normoglycemic healthy subjects, the evaluated biomarkers of atherosclerotic process didn’t show any significant association with cardiac, carotid and vascular TOD while age and BP are its principal predictors. |
| first_indexed | 2024-03-12T00:39:18Z |
| format | Article |
| id | doaj.art-942e686201854878ada0a272682fb5f8 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:18Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-942e686201854878ada0a272682fb5f82023-09-15T08:45:22ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992018-09-0127526227010.1080/08037051.2018.14610101461010In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkersAlessandro Maloberti0Francesca Farina1Marco Carbonaro2Enrico Piccinelli3Ilaria Bassi4Francesco Pansera5Guido Grassi6Giuseppe Mancia7Paola Palestini8Cristina Giannattasio9Ospedale Niguarda Ca’ GrandaMilano-Bicocca UniversityMilano-Bicocca UniversityOspedale Niguarda Ca’ GrandaOspedale Niguarda Ca’ GrandaOspedale Niguarda Ca’ GrandaMilano-Bicocca UniversityMilano-Bicocca UniversityMilano-Bicocca UniversityOspedale Niguarda Ca’ GrandaPurpose: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI‐1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases. Materials and Methods: 480 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Hypertrophy (LVH) and Intima Media Thickness (IMT) and carotid plaque presence) grouped together under carotid TOD. Results: 3.1% of the subjects showed a PWV higher than 10 m/sec with those subjects exerting significantly lower values of P-Selectine (0.068 ± 0.015 vs 0.08 ± 0.036 mg/L, p = .014). 8.8% of the subjects showed carotid TOD that was associated with higher Cystatin-C values (0.67 ± 0.17 vs 0.63 ± 0.14 mg/L, p = .045). Finally 23.8% of the subjects showed LVH with no significant differences regarding biomarkers. Despite some significant correlations between biomarkers and TOD, at the multivariate analysis none came out to be as significant predictor of the assessed TOD. Conclusions: in normotensive and normoglycemic healthy subjects, the evaluated biomarkers of atherosclerotic process didn’t show any significant association with cardiac, carotid and vascular TOD while age and BP are its principal predictors.http://dx.doi.org/10.1080/08037051.2018.1461010cystatin-cplasminogen activator inhibitor-1tissue inhibitor metalloproteinases-1p-selectincarotid intima media thicknesscarotid plaquepulse wave velocityleft ventricular mass index |
| spellingShingle | Alessandro Maloberti Francesca Farina Marco Carbonaro Enrico Piccinelli Ilaria Bassi Francesco Pansera Guido Grassi Giuseppe Mancia Paola Palestini Cristina Giannattasio In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers Blood Pressure cystatin-c plasminogen activator inhibitor-1 tissue inhibitor metalloproteinases-1 p-selectin carotid intima media thickness carotid plaque pulse wave velocity left ventricular mass index |
| title | In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| title_full | In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| title_fullStr | In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| title_full_unstemmed | In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| title_short | In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| title_sort | in healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers |
| topic | cystatin-c plasminogen activator inhibitor-1 tissue inhibitor metalloproteinases-1 p-selectin carotid intima media thickness carotid plaque pulse wave velocity left ventricular mass index |
| url | http://dx.doi.org/10.1080/08037051.2018.1461010 |
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