Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model

Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model

Abstract The ketogenic diet (KD) is a high fat and low carbohydrate diet that produces ketone bodies through imitation of starvation. The combination of KD and Bevacizumab (Bev), a VEGF inhibitor, is considered to further reduce the supply of glucose to the tumor. The metabolite changes in U87 gliob...

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Bibliographic Details
Main Authors: Masahiro Maeyama, Kazuhiro Tanaka, Masamitsu Nishihara, Yasuhiro Irino, Masakazu Shinohara, Hiroaki Nagashima, Hirotomo Tanaka, Satoshi Nakamizo, Mitsuru Hashiguchi, Yuichi Fujita, Masaaki Kohta, Eiji Kohmura, Takashi Sasayama
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79465-x

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