Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi

Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi

Deletion of phenylalanine 508 (∆F508) of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel protein is the leading cause of Cystic Fibrosis (CF). Here, we report the analysis of CFTR and ∆F508-CFTR interactomes using BioID (proximity-dependent biotin identification), a tech...

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Bibliographic Details
Main Authors: Melissa Iazzi, Audrey Astori, Jonathan St-Germain, Brian Raught, Gagan D. Gupta
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
CFTR interactions
CFTR modulators
cystic fibrosis
Orkambi
theratyping
protein trafficking
Online Access:https://www.mdpi.com/1422-0067/23/5/2442

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