Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

Abstract The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical translation of the expanded repeat results in abundant poly‐GA inclusion pathology throughout the CNS. (GA)149‐CFP expression in mice trig...

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Bibliographic Details
Main Authors: Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer
Format: Article
Language:English
Published: Springer Nature 2019-12-01
Series:EMBO Molecular Medicine
Subjects:
amyotrophic lateral sclerosis
C9orf72
frontotemporal dementia
immunotherapy
neurodegeneration
Online Access:https://doi.org/10.15252/emmm.201910919

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