Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D

Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D

The mortality of sepsis and septic shock remains high worldwide. Neutrophil extracellular traps (NETs) release is a major cause of organ failure and mortality in sepsis. Targeting Gasdermin D (GSDMD) can restrain NETs formation, which is promising for sepsis management. However, no medicine is ident...

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Bibliographic Details
Main Authors: Ting Shang, Zhi-Sen Zhang, Xin-Tong Wang, Jing Chang, Meng-En Zhou, Ming Lyu, Shuang He, Jian Yang, Yan-Xu Chang, Yuefei Wang, Ming-Chun Li, Xiumei Gao, Yan Zhu, Yuxin Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
sepsis-induced lung injury
Xuebijing injection
neutrophil recruitment
neutrophil extracellular traps
Gasdermin D
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1054176/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1054176/full

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