Combination treatment of parotid salivary gland cancer
Background: Cancer of the parotid salivary gland (PSG) accounts for more than a half of all cases of salivary gland malignancies. Its treatment strategy remains a matter of debate.Aim: To identify factors significantly associated with the 3-year survival of patients with PSG cancer after combination...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
MONIKI
2017-08-01
|
| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/562 |
| _version_ | 1818642367084756992 |
|---|---|
| author | A. S. Balkanov O. A. Bychenkov A. M. Sipkin L. E. Gaganov |
| author_facet | A. S. Balkanov O. A. Bychenkov A. M. Sipkin L. E. Gaganov |
| author_sort | A. S. Balkanov |
| collection | DOAJ |
| description | Background: Cancer of the parotid salivary gland (PSG) accounts for more than a half of all cases of salivary gland malignancies. Its treatment strategy remains a matter of debate.Aim: To identify factors significantly associated with the 3-year survival of patients with PSG cancer after combination treatment.Materials and methods: Thirty nine patients with morphologically confirmed PSG cancer (T1-4N0) were recruited into the study. Surgery (partial or total parotidectomy without the cervical lymphatic node dissection) was performed in 32 patients. The most frequent diagnosis (n = 10; 25.6% of all cases) was adenocarcinoma. Radiation to PSG and the regional lymphatic nodes was used in 15 patients as neoadjuvant and in 24 as adjuvant regimen. Three-year survival rates were analyzed in 36 patients by the Kaplan-Meier method, with consideration of their sex, age and the sequence of surgical and radiation treatment.Results: The 3-year survival after combination treatment of PSG cancer patients was 82.7%. Women, patients above 60 years of age and those who received adjuvant radiation therapy demonstrated a trend towards better 3-year survival, although it was non-significant (p > 0.05).Conclusion: Combination strategy remains an effective approach to PSG cancer irrespective of age and sex of patients. The use of radiation therapy as a single modality is possible only in exceptional cases. |
| first_indexed | 2024-12-16T23:41:56Z |
| format | Article |
| id | doaj.art-94323ee45ebc446986f9c97b81559c36 |
| institution | Directory Open Access Journal |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| last_indexed | 2024-12-16T23:41:56Z |
| publishDate | 2017-08-01 |
| publisher | MONIKI |
| record_format | Article |
| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj.art-94323ee45ebc446986f9c97b81559c362022-12-21T22:11:35ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942017-08-0145430931310.18786/2072-0505-2017-45-4-309-313462Combination treatment of parotid salivary gland cancerA. S. Balkanov0O. A. Bychenkov1A. M. Sipkin2L. E. Gaganov3Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Background: Cancer of the parotid salivary gland (PSG) accounts for more than a half of all cases of salivary gland malignancies. Its treatment strategy remains a matter of debate.Aim: To identify factors significantly associated with the 3-year survival of patients with PSG cancer after combination treatment.Materials and methods: Thirty nine patients with morphologically confirmed PSG cancer (T1-4N0) were recruited into the study. Surgery (partial or total parotidectomy without the cervical lymphatic node dissection) was performed in 32 patients. The most frequent diagnosis (n = 10; 25.6% of all cases) was adenocarcinoma. Radiation to PSG and the regional lymphatic nodes was used in 15 patients as neoadjuvant and in 24 as adjuvant regimen. Three-year survival rates were analyzed in 36 patients by the Kaplan-Meier method, with consideration of their sex, age and the sequence of surgical and radiation treatment.Results: The 3-year survival after combination treatment of PSG cancer patients was 82.7%. Women, patients above 60 years of age and those who received adjuvant radiation therapy demonstrated a trend towards better 3-year survival, although it was non-significant (p > 0.05).Conclusion: Combination strategy remains an effective approach to PSG cancer irrespective of age and sex of patients. The use of radiation therapy as a single modality is possible only in exceptional cases.https://www.almclinmed.ru/jour/article/view/562parotid salivary gland cancerparotidectomyradiation therapysurvival |
| spellingShingle | A. S. Balkanov O. A. Bychenkov A. M. Sipkin L. E. Gaganov Combination treatment of parotid salivary gland cancer Alʹmanah Kliničeskoj Mediciny parotid salivary gland cancer parotidectomy radiation therapy survival |
| title | Combination treatment of parotid salivary gland cancer |
| title_full | Combination treatment of parotid salivary gland cancer |
| title_fullStr | Combination treatment of parotid salivary gland cancer |
| title_full_unstemmed | Combination treatment of parotid salivary gland cancer |
| title_short | Combination treatment of parotid salivary gland cancer |
| title_sort | combination treatment of parotid salivary gland cancer |
| topic | parotid salivary gland cancer parotidectomy radiation therapy survival |
| url | https://www.almclinmed.ru/jour/article/view/562 |
| work_keys_str_mv | AT asbalkanov combinationtreatmentofparotidsalivaryglandcancer AT oabychenkov combinationtreatmentofparotidsalivaryglandcancer AT amsipkin combinationtreatmentofparotidsalivaryglandcancer AT legaganov combinationtreatmentofparotidsalivaryglandcancer |