Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis
AimsAutism is a multifaceted developmental disorder of the nervous system, that necessitates novel therapeutic approaches beyond traditional medications and psychosomatic therapy, such as appropriate sensory integration training. This systematic mapping review aims to synthesize existing knowledge o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1328240/full |
| _version_ | 1827367445945384960 |
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| author | Yutong Li Jing Lu Jing Zhang Wenxin Gui Weijie Xie Weijie Xie |
| author_facet | Yutong Li Jing Lu Jing Zhang Wenxin Gui Weijie Xie Weijie Xie |
| author_sort | Yutong Li |
| collection | DOAJ |
| description | AimsAutism is a multifaceted developmental disorder of the nervous system, that necessitates novel therapeutic approaches beyond traditional medications and psychosomatic therapy, such as appropriate sensory integration training. This systematic mapping review aims to synthesize existing knowledge on enriching environmental interventions as an alternative avenue for improving autism, guiding future research and practice.MethodA comprehensive search using the terms ASD and Enriched Environment was conducted across PubMed, EMBASE, ISI, Cochrane, and OVID databases. Most of the literature included in this review was derived from animal model experiments, with a particular focus on assessing the effect of EE on autism-like behavior, along with related pathways and molecular mechanisms. Following extensive group discussion and screening, a total of 19 studies were included for analysis.ResultsEnriched environmental interventions exhibited the potential to induce both behavioral and biochemical changes, ameliorating autism-like behaviors in animal models. These improvements were attributed to the targeting of BDNF-related pathways, enhanced neurogenesis, and the regulation of glial inflammation.ConclusionThis paper underscores the positive impact of enriched environmental interventions on autism through a review of existing literature. The findings contribute to a deeper understanding of the underlying brain mechanisms associated with this intervention. |
| first_indexed | 2024-03-08T09:06:34Z |
| format | Article |
| id | doaj.art-94329153b5624361ab2084bf86cc7430 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-08T09:06:34Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-94329153b5624361ab2084bf86cc74302024-02-01T04:39:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-02-011510.3389/fpsyt.2024.13282401328240Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysisYutong Li0Jing Lu1Jing Zhang2Wenxin Gui3Weijie Xie4Weijie Xie5School of Mental Health, Wenzhou Medical University, Wenzhou, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaDepartment of Sports Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, ChinaAimsAutism is a multifaceted developmental disorder of the nervous system, that necessitates novel therapeutic approaches beyond traditional medications and psychosomatic therapy, such as appropriate sensory integration training. This systematic mapping review aims to synthesize existing knowledge on enriching environmental interventions as an alternative avenue for improving autism, guiding future research and practice.MethodA comprehensive search using the terms ASD and Enriched Environment was conducted across PubMed, EMBASE, ISI, Cochrane, and OVID databases. Most of the literature included in this review was derived from animal model experiments, with a particular focus on assessing the effect of EE on autism-like behavior, along with related pathways and molecular mechanisms. Following extensive group discussion and screening, a total of 19 studies were included for analysis.ResultsEnriched environmental interventions exhibited the potential to induce both behavioral and biochemical changes, ameliorating autism-like behaviors in animal models. These improvements were attributed to the targeting of BDNF-related pathways, enhanced neurogenesis, and the regulation of glial inflammation.ConclusionThis paper underscores the positive impact of enriched environmental interventions on autism through a review of existing literature. The findings contribute to a deeper understanding of the underlying brain mechanisms associated with this intervention.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1328240/fullenriched environmentautistic spectrum disorder (ASD)neurogenesissynaptic plasticityhippocampusvalproic acid (VPA) |
| spellingShingle | Yutong Li Jing Lu Jing Zhang Wenxin Gui Weijie Xie Weijie Xie Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis Frontiers in Psychiatry enriched environment autistic spectrum disorder (ASD) neurogenesis synaptic plasticity hippocampus valproic acid (VPA) |
| title | Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis |
| title_full | Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis |
| title_fullStr | Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis |
| title_full_unstemmed | Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis |
| title_short | Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis |
| title_sort | molecular insights into enriched environments and behavioral improvements in autism a systematic review and meta analysis |
| topic | enriched environment autistic spectrum disorder (ASD) neurogenesis synaptic plasticity hippocampus valproic acid (VPA) |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1328240/full |
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