Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants
<p>Abstract</p> <p>Background</p> <p>Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).</p> <p>Results</p> <p>In t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-07-01
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| Series: | BMC Immunology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2172/13/35 |
| _version_ | 1811280925807345664 |
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| author | Wang Jennifer P Zhang Lei Madera Rachel F Woda Marcia Libraty Daniel H |
| author_facet | Wang Jennifer P Zhang Lei Madera Rachel F Woda Marcia Libraty Daniel H |
| author_sort | Wang Jennifer P |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).</p> <p>Results</p> <p>In this study, we identified sex differences in human infant pDC interferon-α production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-α production following R-848 challenge.</p> <p>Conclusions</p> <p>Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.</p> |
| first_indexed | 2024-04-13T01:23:16Z |
| format | Article |
| id | doaj.art-94343e7f2097446bb6c4129213eb8fa8 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-04-13T01:23:16Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-94343e7f2097446bb6c4129213eb8fa82022-12-22T03:08:41ZengBMCBMC Immunology1471-21722012-07-011313510.1186/1471-2172-13-35Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infantsWang Jennifer PZhang LeiMadera Rachel FWoda MarciaLibraty Daniel H<p>Abstract</p> <p>Background</p> <p>Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).</p> <p>Results</p> <p>In this study, we identified sex differences in human infant pDC interferon-α production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-α production following R-848 challenge.</p> <p>Conclusions</p> <p>Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.</p>http://www.biomedcentral.com/1471-2172/13/35pDCIFN-αTNF-αInfantTLR7 |
| spellingShingle | Wang Jennifer P Zhang Lei Madera Rachel F Woda Marcia Libraty Daniel H Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants BMC Immunology pDC IFN-α TNF-α Infant TLR7 |
| title | Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants |
| title_full | Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants |
| title_fullStr | Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants |
| title_full_unstemmed | Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants |
| title_short | Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants |
| title_sort | plasmacytoid dendritic cell interferon α production to r 848 stimulation is decreased in male infants |
| topic | pDC IFN-α TNF-α Infant TLR7 |
| url | http://www.biomedcentral.com/1471-2172/13/35 |
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