Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study
Rationale COPD is the third leading cause of death in the United States. Sphingolipids, structural membrane constituents that play a role in cellular stress and apoptosis signalling, may be involved in lung function. Methods In the Cardiovascular Health Study, a prospective cohort of older adults, w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-04-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/2/00346-2022.full |
| _version_ | 1827931452450275328 |
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| author | Arya R. Gharib Paul N. Jensen Bruce M. Psaty Andrew N. Hoofnagle David Siscovick Sina A. Gharib Colleen M. Sitlani Nona Sotoodehnia Rozenn N. Lemaitre |
| author_facet | Arya R. Gharib Paul N. Jensen Bruce M. Psaty Andrew N. Hoofnagle David Siscovick Sina A. Gharib Colleen M. Sitlani Nona Sotoodehnia Rozenn N. Lemaitre |
| author_sort | Arya R. Gharib |
| collection | DOAJ |
| description | Rationale
COPD is the third leading cause of death in the United States. Sphingolipids, structural membrane constituents that play a role in cellular stress and apoptosis signalling, may be involved in lung function.
Methods
In the Cardiovascular Health Study, a prospective cohort of older adults, we cross-sectionally examined the association of plasma levels of 17 sphingolipid species with lung function and COPD. Multivariable linear regression and logistic regression were used to evaluate associations of sphingolipid concentrations with forced expiratory volume in 1 s (FEV1) and odds of COPD, respectively.
Results
Of the 17 sphingolipids evaluated, ceramide-18 (Cer-18) and sphingomyelin-18 (SM-18) were associated with lower FEV1 values (–0.061 L per two-fold higher Cer-18, p=0.001; −0.092 L per two-fold higher SM-18, p=0.002) after correction for multiple testing. Several other associations were significant at a 0.05 level, but did not reach statistical significance after correction for multiple testing. Specifically, Cer-18 and SM-18 were associated with higher odds of COPD (odds ratio per two-fold higher Cer-18 1.29, p=0.03 and SM-18 1.73, p=0.008). Additionally, Cer-16 and SM-16 were associated with lower FEV1 values, and Cer-14, SM-14 and SM-16 with a higher odds of COPD.
Conclusion
In this large cross-sectional study, specific ceramides and sphingomyelins were associated with reduced lung function in a population-based study. Future studies are needed to examine whether these biomarkers are associated with longitudinal change in FEV1 within individuals or with incident COPD. |
| first_indexed | 2024-03-13T06:51:47Z |
| format | Article |
| id | doaj.art-943a08c3d26f4ec785d2815f8ca7e6b8 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:51:47Z |
| publishDate | 2023-04-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-943a08c3d26f4ec785d2815f8ca7e6b82023-06-07T13:31:07ZengEuropean Respiratory SocietyERJ Open Research2312-05412023-04-019210.1183/23120541.00346-202200346-2022Plasma sphingolipids, lung function and COPD: the Cardiovascular Health StudyArya R. Gharib0Paul N. Jensen1Bruce M. Psaty2Andrew N. Hoofnagle3David Siscovick4Sina A. Gharib5Colleen M. Sitlani6Nona Sotoodehnia7Rozenn N. Lemaitre8 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Department of Laboratory Medicine, University of Washington, Seattle, WA, USA New York Academy of Medicine, New York, NY, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA Rationale COPD is the third leading cause of death in the United States. Sphingolipids, structural membrane constituents that play a role in cellular stress and apoptosis signalling, may be involved in lung function. Methods In the Cardiovascular Health Study, a prospective cohort of older adults, we cross-sectionally examined the association of plasma levels of 17 sphingolipid species with lung function and COPD. Multivariable linear regression and logistic regression were used to evaluate associations of sphingolipid concentrations with forced expiratory volume in 1 s (FEV1) and odds of COPD, respectively. Results Of the 17 sphingolipids evaluated, ceramide-18 (Cer-18) and sphingomyelin-18 (SM-18) were associated with lower FEV1 values (–0.061 L per two-fold higher Cer-18, p=0.001; −0.092 L per two-fold higher SM-18, p=0.002) after correction for multiple testing. Several other associations were significant at a 0.05 level, but did not reach statistical significance after correction for multiple testing. Specifically, Cer-18 and SM-18 were associated with higher odds of COPD (odds ratio per two-fold higher Cer-18 1.29, p=0.03 and SM-18 1.73, p=0.008). Additionally, Cer-16 and SM-16 were associated with lower FEV1 values, and Cer-14, SM-14 and SM-16 with a higher odds of COPD. Conclusion In this large cross-sectional study, specific ceramides and sphingomyelins were associated with reduced lung function in a population-based study. Future studies are needed to examine whether these biomarkers are associated with longitudinal change in FEV1 within individuals or with incident COPD.http://openres.ersjournals.com/content/9/2/00346-2022.full |
| spellingShingle | Arya R. Gharib Paul N. Jensen Bruce M. Psaty Andrew N. Hoofnagle David Siscovick Sina A. Gharib Colleen M. Sitlani Nona Sotoodehnia Rozenn N. Lemaitre Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study ERJ Open Research |
| title | Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study |
| title_full | Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study |
| title_fullStr | Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study |
| title_full_unstemmed | Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study |
| title_short | Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study |
| title_sort | plasma sphingolipids lung function and copd the cardiovascular health study |
| url | http://openres.ersjournals.com/content/9/2/00346-2022.full |
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