Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure
Summary: Structural and functional deficits in brain connectivity are reported in patients with fetal alcohol spectrum disorders (FASDs), but whether and how prenatal alcohol exposure (PAE) affects axonal development of neurons and disrupts wiring between brain regions is unknown. Here, we develop a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723010318 |
| _version_ | 1797737994761797632 |
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| author | Mike Altounian Anaïs Bellon Fanny Mann |
| author_facet | Mike Altounian Anaïs Bellon Fanny Mann |
| author_sort | Mike Altounian |
| collection | DOAJ |
| description | Summary: Structural and functional deficits in brain connectivity are reported in patients with fetal alcohol spectrum disorders (FASDs), but whether and how prenatal alcohol exposure (PAE) affects axonal development of neurons and disrupts wiring between brain regions is unknown. Here, we develop a mouse model of moderate alcohol exposure during prenatal brain wiring to study the effects of PAE on corpus callosum (CC) development. PAE induces aberrant navigation of interhemispheric CC axons that persists even after exposure ends, leading to ectopic termination in the contralateral cortex. The neuronal miR-17-5p and its target ephrin type A receptor 4 (EphA4) mediate the effect of alcohol on the contralateral targeting of CC axons. Thus, altered microRNA-mediated regulation of axonal guidance may have implications for interhemispheric cortical connectivity and associated behaviors in FASD. |
| first_indexed | 2024-03-12T13:36:31Z |
| format | Article |
| id | doaj.art-943d7cf12be64aa588902bdb2c5e2790 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-12T13:36:31Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-943d7cf12be64aa588902bdb2c5e27902023-08-24T04:35:03ZengElsevierCell Reports2211-12472023-09-01429113020Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposureMike Altounian0Anaïs Bellon1Fanny Mann2Aix Marseille University, CNRS, IBDM, Marseille, FranceAix Marseille University, INSERM, INMED, Marseille, FranceAix Marseille University, CNRS, IBDM, Marseille, France; Corresponding authorSummary: Structural and functional deficits in brain connectivity are reported in patients with fetal alcohol spectrum disorders (FASDs), but whether and how prenatal alcohol exposure (PAE) affects axonal development of neurons and disrupts wiring between brain regions is unknown. Here, we develop a mouse model of moderate alcohol exposure during prenatal brain wiring to study the effects of PAE on corpus callosum (CC) development. PAE induces aberrant navigation of interhemispheric CC axons that persists even after exposure ends, leading to ectopic termination in the contralateral cortex. The neuronal miR-17-5p and its target ephrin type A receptor 4 (EphA4) mediate the effect of alcohol on the contralateral targeting of CC axons. Thus, altered microRNA-mediated regulation of axonal guidance may have implications for interhemispheric cortical connectivity and associated behaviors in FASD.http://www.sciencedirect.com/science/article/pii/S2211124723010318CP: NeuroscienceCP: Molecular biology |
| spellingShingle | Mike Altounian Anaïs Bellon Fanny Mann Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure Cell Reports CP: Neuroscience CP: Molecular biology |
| title | Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| title_full | Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| title_fullStr | Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| title_full_unstemmed | Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| title_short | Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| title_sort | neuronal mir 17 5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure |
| topic | CP: Neuroscience CP: Molecular biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723010318 |
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