Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014
Abstract Background The objective of this study is to describe the changes in prescribing practices of antibiotics to treat acute pyelonephritis (APN) in Korea. Methods The claim data base of the Health Insurance Review and Assessment Service in Korea was used to select patients with ICD-10 codes N1...
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| Language: | English |
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BMC
2019-06-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4191-0 |
| _version_ | 1818493551135162368 |
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| author | Bongyoung Kim Rangmi Myung Myoung-jae Lee Jieun Kim Hyunjoo Pai |
| author_facet | Bongyoung Kim Rangmi Myung Myoung-jae Lee Jieun Kim Hyunjoo Pai |
| author_sort | Bongyoung Kim |
| collection | DOAJ |
| description | Abstract Background The objective of this study is to describe the changes in prescribing practices of antibiotics to treat acute pyelonephritis (APN) in Korea. Methods The claim data base of the Health Insurance Review and Assessment Service in Korea was used to select patients with ICD-10 codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, not specified as acute nor chronic) as the primary discharge diagnosis during 2010–2014. Consumption of each class of antibiotics was converted to Defined Daily Dose (DDD)/event. Results Throughout the five-year period, the average antibiotic consumption were 11.3 DDD per inpatient event and 6.0 DDD per outpatient event. The annual average antibiotic consumption increased for inpatients (P = 0.002), but remained stable for outpatients (P = 0.066). The use of parenteral antibiotics increased for inpatients (P < 0.001), but decreased for outpatients (P = 0.017). As for the the antibiotic classes, 3rd generation cephalosporins (3rd CEPs) was the most commonly prescribed (41.4%) for inpatients, followed by fluoroquinolones (FQs) (28.5%); for outpatient, FQs (54.8%) was the most commonly prescribed, followed by 3rd CEPs (13.1%). The use of 3rd CEPs (P < 0.001), beta-lactam/beta-lactamase inhibitors (P = 0.007), and carbapenems (P < 0.001) increased substantially for the treatment of hospitalized APN patients. In particular, carbapenems use increased 3.1-fold over the 5 years. Conclusions Prescription of broad-spectrum antibiotics increased much for the treatment of APN in Korea during 2010–2014. |
| first_indexed | 2024-12-10T17:56:49Z |
| format | Article |
| id | doaj.art-943fc3ebf0954e3d84fed4a4b25db4f3 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-10T17:56:49Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-943fc3ebf0954e3d84fed4a4b25db4f32022-12-22T01:38:55ZengBMCBMC Infectious Diseases1471-23342019-06-011911710.1186/s12879-019-4191-0Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014Bongyoung Kim0Rangmi Myung1Myoung-jae Lee2Jieun Kim3Hyunjoo Pai4Department of Internal Medicine, College of Medicine, Hanyang UniversityDepartment of Economics, College of Political Science & Economics, Korea UniversityDepartment of Economics, College of Political Science & Economics, Korea UniversityDepartment of Internal Medicine, College of Medicine, Hanyang UniversityDepartment of Internal Medicine, College of Medicine, Hanyang UniversityAbstract Background The objective of this study is to describe the changes in prescribing practices of antibiotics to treat acute pyelonephritis (APN) in Korea. Methods The claim data base of the Health Insurance Review and Assessment Service in Korea was used to select patients with ICD-10 codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, not specified as acute nor chronic) as the primary discharge diagnosis during 2010–2014. Consumption of each class of antibiotics was converted to Defined Daily Dose (DDD)/event. Results Throughout the five-year period, the average antibiotic consumption were 11.3 DDD per inpatient event and 6.0 DDD per outpatient event. The annual average antibiotic consumption increased for inpatients (P = 0.002), but remained stable for outpatients (P = 0.066). The use of parenteral antibiotics increased for inpatients (P < 0.001), but decreased for outpatients (P = 0.017). As for the the antibiotic classes, 3rd generation cephalosporins (3rd CEPs) was the most commonly prescribed (41.4%) for inpatients, followed by fluoroquinolones (FQs) (28.5%); for outpatient, FQs (54.8%) was the most commonly prescribed, followed by 3rd CEPs (13.1%). The use of 3rd CEPs (P < 0.001), beta-lactam/beta-lactamase inhibitors (P = 0.007), and carbapenems (P < 0.001) increased substantially for the treatment of hospitalized APN patients. In particular, carbapenems use increased 3.1-fold over the 5 years. Conclusions Prescription of broad-spectrum antibiotics increased much for the treatment of APN in Korea during 2010–2014.http://link.springer.com/article/10.1186/s12879-019-4191-0Acute pyelonephritisAntibiotic consumptionResistanceStewardshipNational health insuranceKorea |
| spellingShingle | Bongyoung Kim Rangmi Myung Myoung-jae Lee Jieun Kim Hyunjoo Pai Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 BMC Infectious Diseases Acute pyelonephritis Antibiotic consumption Resistance Stewardship National health insurance Korea |
| title | Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 |
| title_full | Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 |
| title_fullStr | Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 |
| title_full_unstemmed | Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 |
| title_short | Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010–2014 |
| title_sort | trend of antibiotics usage for acute pyelonephritis in korea based on national health insurance data 2010 2014 |
| topic | Acute pyelonephritis Antibiotic consumption Resistance Stewardship National health insurance Korea |
| url | http://link.springer.com/article/10.1186/s12879-019-4191-0 |
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