Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

<p>Abstract</p> <p>Background</p> <p>Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cance...

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Bibliographic Details
Main Authors:	Heibein Allan D, Guo Baoqing, Sprowl Jason A, MacLean David A, Parissenti Amadeo M
Format:	Article
Language:	English
Published:	BMC 2012-08-01
Series:	BMC Cancer
Subjects:	Doxorubicin Resistance Gene profiling PharmGKB Pharmacokinetics Aldo-keto reductases Cytotoxicity Lysosome DNA-binding Drug localization
Online Access:	http://www.biomedcentral.com/1471-2407/12/381

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