Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

Progressive destruction of pancreatic islet β-cells by immune cells is a primary feature of type 1 diabetes (T1D) and therapies that can restore the functional β-cell mass are needed to alleviate disease progression. Here, we report the use of mesenchymal stromal/stem cells (MSCs) for the production...

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Bibliographic Details
Main Authors: Marie-Claude Gaudreau, Radhika R. Gudi, Gongbo Li, Benjamin M. Johnson, Chenthamarakshan Vasu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-02-01
Series:Autoimmunity
Subjects:
mesenchymal stem cells
type 1 diabetes
gastrin
autoimmunity
insulitis
immune modulation
Online Access:http://dx.doi.org/10.1080/08916934.2021.2012165

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