Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats
Methanolic extract of Balanites aegyptiaca (L.) Delile (leaves), was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in Wistar rats; by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutama...
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| Format: | Article |
| Language: | English |
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School of Medicine and Pharmacy, Rabat, Morocco
2016-03-01
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| Series: | Arabian Journal of Medicinal and Aromatic Plants |
| Subjects: | |
| Online Access: | https://revues.imist.ma/index.php/AJMAP/article/view/4860 |
| _version_ | 1818606004741341184 |
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| author | Elwaleed E. Ibrahim Abd-Elwahab H. Mohamed Assad Khalid Ashraf N. Abdalla |
| author_facet | Elwaleed E. Ibrahim Abd-Elwahab H. Mohamed Assad Khalid Ashraf N. Abdalla |
| author_sort | Elwaleed E. Ibrahim |
| collection | DOAJ |
| description | Methanolic extract of Balanites aegyptiaca (L.) Delile (leaves), was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in Wistar rats; by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin. Histological studies were also carried out to support our hypothesis. Administration of the extract (200 and 400 mg/kg) orally markedly prevented CCl4-induced elevation of serum GPT, GOT, ALP and total bilirubin levels. A comparative histopathological study of liver in treated groups exhibited similarity to normal tissue architecture, compared to CCl4-treated group. |
| first_indexed | 2024-12-16T14:03:58Z |
| format | Article |
| id | doaj.art-94440eec2b4d4d4f888e19a38d5fb2a1 |
| institution | Directory Open Access Journal |
| issn | 2458-5920 |
| language | English |
| last_indexed | 2024-12-16T14:03:58Z |
| publishDate | 2016-03-01 |
| publisher | School of Medicine and Pharmacy, Rabat, Morocco |
| record_format | Article |
| series | Arabian Journal of Medicinal and Aromatic Plants |
| spelling | doaj.art-94440eec2b4d4d4f888e19a38d5fb2a12022-12-21T22:28:58ZengSchool of Medicine and Pharmacy, Rabat, MoroccoArabian Journal of Medicinal and Aromatic Plants2458-59202016-03-0121596710.48347/IMIST.PRSM/ajmap-v2i1.48603204Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in ratsElwaleed E. Ibrahim0Abd-Elwahab H. Mohamed1Assad Khalid2Ashraf N. Abdalla3Department of Pharmacology & Toxicology, National Centre for Research, MAPRI, Khartoum, Sudan.Department of Pharmacology & Toxicology, National Centre for Research, MAPRI, Khartoum, Sudan.Department of Medical Biochemistry, National Centre for Research, MAPRI, Khartoum, Sudan.College of Pharmacy, UmmAlqura University, Makkah, KSA.Methanolic extract of Balanites aegyptiaca (L.) Delile (leaves), was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in Wistar rats; by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin. Histological studies were also carried out to support our hypothesis. Administration of the extract (200 and 400 mg/kg) orally markedly prevented CCl4-induced elevation of serum GPT, GOT, ALP and total bilirubin levels. A comparative histopathological study of liver in treated groups exhibited similarity to normal tissue architecture, compared to CCl4-treated group.https://revues.imist.ma/index.php/AJMAP/article/view/4860balanites aegyptiaca (l.) delilehepatoprotective |
| spellingShingle | Elwaleed E. Ibrahim Abd-Elwahab H. Mohamed Assad Khalid Ashraf N. Abdalla Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats Arabian Journal of Medicinal and Aromatic Plants balanites aegyptiaca (l.) delile hepatoprotective |
| title | Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats |
| title_full | Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats |
| title_fullStr | Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats |
| title_full_unstemmed | Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats |
| title_short | Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats |
| title_sort | hepatoprotective effect of balanites aegyptiaca l delile leaves against carbon tetrachloride induced hepatic damage in rats |
| topic | balanites aegyptiaca (l.) delile hepatoprotective |
| url | https://revues.imist.ma/index.php/AJMAP/article/view/4860 |
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