New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity
Polymethylmethacrylate (PMMA) is the most commonly used bone void filler in orthopedic surgery. However, the biocompatibility and radiopacity of PMMA are insufficient for such applications. In addition to insufficient biocompatibility, the microbial infection of medical implants is one of the freque...
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MDPI AG
2023-10-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/8/6/488 |
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| author | Olga Bakina Natalia Svarovskaya Ludmila Ivanova Elena Glazkova Nikolay Rodkevich Vladyslav Evstigneev Maxim Evstigneev Andrey Mosunov Marat Lerner |
| author_facet | Olga Bakina Natalia Svarovskaya Ludmila Ivanova Elena Glazkova Nikolay Rodkevich Vladyslav Evstigneev Maxim Evstigneev Andrey Mosunov Marat Lerner |
| author_sort | Olga Bakina |
| collection | DOAJ |
| description | Polymethylmethacrylate (PMMA) is the most commonly used bone void filler in orthopedic surgery. However, the biocompatibility and radiopacity of PMMA are insufficient for such applications. In addition to insufficient biocompatibility, the microbial infection of medical implants is one of the frequent causes of failure in bone reconstruction. In the present work, the preparation of a novel PMMA-based hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO composite with heterophase ZnFe<sub>2</sub>O<sub>4</sub>/ZnO NPs as an antimicrobial agent was described. ZnFe<sub>2</sub>O<sub>4</sub>/ZnO nanoparticles were produced using the electrical explosion of zinc and iron twisted wires in an oxygen-containing atmosphere. This simple, highly productive, and inexpensive nanoparticle fabrication approach could be readily adapted to different applications. From the findings, the presented composite material showed significant antibacterial activity (more than 99% reduction) against <i>P. aeruginosa</i>, <i>S. aureus</i>, and MRSA, and 100% antifungal activity against <i>C. albicans,</i> as a result of the combined use of both ZnO and ZnFe<sub>2</sub>O<sub>4</sub>. The composite showed excellent biocompatibility against the sensitive fibroblast cell line 3T3. The more-than-70% cell viability was observed after 1–3 days incubation of the sample. The developed composite material could be a potential material for the fabrication of 3D-printed implants. |
| first_indexed | 2024-03-10T21:24:39Z |
| format | Article |
| id | doaj.art-9446223866fb4d3e8f63292a77bc20a0 |
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| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-10T21:24:39Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-9446223866fb4d3e8f63292a77bc20a02023-11-19T15:48:51ZengMDPI AGBiomimetics2313-76732023-10-018648810.3390/biomimetics8060488New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low ToxicityOlga Bakina0Natalia Svarovskaya1Ludmila Ivanova2Elena Glazkova3Nikolay Rodkevich4Vladyslav Evstigneev5Maxim Evstigneev6Andrey Mosunov7Marat Lerner8Institute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaInstitute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaInstitute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaInstitute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaInstitute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaSevastopol State University, 33 Universitetskaya Street, 299053 Sevastopol, RussiaSevastopol State University, 33 Universitetskaya Street, 299053 Sevastopol, RussiaSevastopol State University, 33 Universitetskaya Street, 299053 Sevastopol, RussiaInstitute of Strength Physics and Material Science, Siberian Branch of Russian Academy of Science, Av. Akademicheskii, 2/4, 634055 Tomsk, RussiaPolymethylmethacrylate (PMMA) is the most commonly used bone void filler in orthopedic surgery. However, the biocompatibility and radiopacity of PMMA are insufficient for such applications. In addition to insufficient biocompatibility, the microbial infection of medical implants is one of the frequent causes of failure in bone reconstruction. In the present work, the preparation of a novel PMMA-based hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO composite with heterophase ZnFe<sub>2</sub>O<sub>4</sub>/ZnO NPs as an antimicrobial agent was described. ZnFe<sub>2</sub>O<sub>4</sub>/ZnO nanoparticles were produced using the electrical explosion of zinc and iron twisted wires in an oxygen-containing atmosphere. This simple, highly productive, and inexpensive nanoparticle fabrication approach could be readily adapted to different applications. From the findings, the presented composite material showed significant antibacterial activity (more than 99% reduction) against <i>P. aeruginosa</i>, <i>S. aureus</i>, and MRSA, and 100% antifungal activity against <i>C. albicans,</i> as a result of the combined use of both ZnO and ZnFe<sub>2</sub>O<sub>4</sub>. The composite showed excellent biocompatibility against the sensitive fibroblast cell line 3T3. The more-than-70% cell viability was observed after 1–3 days incubation of the sample. The developed composite material could be a potential material for the fabrication of 3D-printed implants.https://www.mdpi.com/2313-7673/8/6/488polymethylmethacrylateantimicrobial nanoparticleselectrical explosion of wirehydroxyapatite |
| spellingShingle | Olga Bakina Natalia Svarovskaya Ludmila Ivanova Elena Glazkova Nikolay Rodkevich Vladyslav Evstigneev Maxim Evstigneev Andrey Mosunov Marat Lerner New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity Biomimetics polymethylmethacrylate antimicrobial nanoparticles electrical explosion of wire hydroxyapatite |
| title | New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity |
| title_full | New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity |
| title_fullStr | New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity |
| title_full_unstemmed | New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity |
| title_short | New PMMA-Based Hydroxyapatite/ZnFe<sub>2</sub>O<sub>4</sub>/ZnO Composite with Antibacterial Performance and Low Toxicity |
| title_sort | new pmma based hydroxyapatite znfe sub 2 sub o sub 4 sub zno composite with antibacterial performance and low toxicity |
| topic | polymethylmethacrylate antimicrobial nanoparticles electrical explosion of wire hydroxyapatite |
| url | https://www.mdpi.com/2313-7673/8/6/488 |
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