The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism
This study aimed to investigate the relationship between quantitative and volumetric parameters of technetium-99-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) imaging and hormonal and biochemical markers in primary hyperparathyroidis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/20/3182 |
| _version_ | 1827721245549920256 |
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| author | Guler Silov Serpil Erdogan Ozbodur |
| author_facet | Guler Silov Serpil Erdogan Ozbodur |
| author_sort | Guler Silov |
| collection | DOAJ |
| description | This study aimed to investigate the relationship between quantitative and volumetric parameters of technetium-99-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) imaging and hormonal and biochemical markers in primary hyperparathyroidism (PHPT) patients with single adenoma. In this retrospective study, 70 patients with a single adenoma who underwent 99mTc-MIBI imaging for the diagnosis of PHPT were examined. Early and delayed MIBI lesion/background ratios (eLBR and dLBR), early and delayed lesion/thyroid ratio (eLTR and dLTR), and retention index (RI) were calculated as planar dual-phase scintigraphy parameters. Adenoma volume (Svol) and parathormone (PTH)/Svol ratio were measured as SPECT/CT-derived parameters. Calcium levels exhibited a positive correlation with eLBR (r = 0.33, <i>p</i> < 0.001), dLBR (r = 0.29, <i>p</i> = 0.01), dLTR (r = 0.31, <i>p</i> < 0.001), and PTH/Svol (r = 0.38, <i>p</i> < 0.001). PTH did not correlate with planar parameters and Svol. Among the imaging parameters, only the PTH/Svol ratio showed a negative correlation with phosphorus levels (r = −0.29, <i>p</i> = 0.02). For predicting disease severity, the PTH/Svol ratio exhibited similar diagnostic performance to PTH and phosphorus levels but outperformed the eLBR and dLBR. Both planar and SPECT-derived parameters can provide valuable insights into the functional status of the parathyroid adenoma and the associated disease severity. PTH/Svol ratio, combining imaging and laboratory findings to provide a more comprehensive approach to patient care, could be an exciting new indicator. |
| first_indexed | 2024-03-10T21:19:51Z |
| format | Article |
| id | doaj.art-9446ad2ead224c4b930ca8f77bacf7ca |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T21:19:51Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9446ad2ead224c4b930ca8f77bacf7ca2023-11-19T16:12:26ZengMDPI AGDiagnostics2075-44182023-10-011320318210.3390/diagnostics13203182The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary HyperparathyroidismGuler Silov0Serpil Erdogan Ozbodur1Department of Nuclear Medicine, Samsun University Faculty of Medicine, Samsun 55200, TurkeyDepartment of Nuclear Medicine, Gazi State Hospital, Samsun Provincial Health Directorate, Samsun 55070, TurkeyThis study aimed to investigate the relationship between quantitative and volumetric parameters of technetium-99-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) imaging and hormonal and biochemical markers in primary hyperparathyroidism (PHPT) patients with single adenoma. In this retrospective study, 70 patients with a single adenoma who underwent 99mTc-MIBI imaging for the diagnosis of PHPT were examined. Early and delayed MIBI lesion/background ratios (eLBR and dLBR), early and delayed lesion/thyroid ratio (eLTR and dLTR), and retention index (RI) were calculated as planar dual-phase scintigraphy parameters. Adenoma volume (Svol) and parathormone (PTH)/Svol ratio were measured as SPECT/CT-derived parameters. Calcium levels exhibited a positive correlation with eLBR (r = 0.33, <i>p</i> < 0.001), dLBR (r = 0.29, <i>p</i> = 0.01), dLTR (r = 0.31, <i>p</i> < 0.001), and PTH/Svol (r = 0.38, <i>p</i> < 0.001). PTH did not correlate with planar parameters and Svol. Among the imaging parameters, only the PTH/Svol ratio showed a negative correlation with phosphorus levels (r = −0.29, <i>p</i> = 0.02). For predicting disease severity, the PTH/Svol ratio exhibited similar diagnostic performance to PTH and phosphorus levels but outperformed the eLBR and dLBR. Both planar and SPECT-derived parameters can provide valuable insights into the functional status of the parathyroid adenoma and the associated disease severity. PTH/Svol ratio, combining imaging and laboratory findings to provide a more comprehensive approach to patient care, could be an exciting new indicator.https://www.mdpi.com/2075-4418/13/20/3182primary hyperparathyroidismdual-phase parathyroid scintigraphySPECT/CTquantitative analysisparathyroid adenoma volume |
| spellingShingle | Guler Silov Serpil Erdogan Ozbodur The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism Diagnostics primary hyperparathyroidism dual-phase parathyroid scintigraphy SPECT/CT quantitative analysis parathyroid adenoma volume |
| title | The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism |
| title_full | The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism |
| title_fullStr | The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism |
| title_full_unstemmed | The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism |
| title_short | The Relationship between Planar and SPECT/CT Parameters and Functional Markers in Primary Hyperparathyroidism |
| title_sort | relationship between planar and spect ct parameters and functional markers in primary hyperparathyroidism |
| topic | primary hyperparathyroidism dual-phase parathyroid scintigraphy SPECT/CT quantitative analysis parathyroid adenoma volume |
| url | https://www.mdpi.com/2075-4418/13/20/3182 |
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