Diabetes mellitus and hypertension as risk factors of acute kidney injury induced by COVID-19: A systematic review and meta-analysis
Introduction Acute kidney injury (AKI) is one of the severe complications of COVID-19. The two distinct medical conditions sharing similar comorbidities are diabetes and hypertension. However, the correlation between AKI and COVID-19 patients with diabetes and/or hypertension, has not been extensive...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2022-12-01
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| Series: | Pneumon |
| Subjects: | |
| Online Access: | http://www.pneumon.org/Diabetes-mellitus-and-hypertension-as-risk-factors-of-acute-kidney-injury-induced,154602,0,2.html |
| Summary: | Introduction
Acute kidney injury (AKI) is one of the severe complications
of COVID-19. The two distinct medical conditions sharing similar comorbidities
are diabetes and hypertension. However, the correlation between AKI and
COVID-19 patients with diabetes and/or hypertension, has not been
extensively discussed. This study aims to assess the risk factors of AKI induced
by COVID-19, using a meta-analysis approach.
Methods
A meta-analysis was carried out by reviewing the latest relevant
studies on online databases such as PubMed, Google Scholar and Medline,
up to 21 March 2022. The required information related to hypertension
and diabetes as the potential risk factors of AKI induced by COVID-19, was
extracted. The association was analyzed using pooled odds ratio (OR) and a
95% confidence interval (95% CI).
Results
We analyzed 29 studies consisting of 10698 AKI patients with
COVID-19 and 20917 controls. Our results show that patients with diabetes
(OR=1.5442; 95% CI: 1.3652–1.7467, p<0.0001, pHet (heterogeneity
test)=0.0001, pE (Egger test)=0.8074) and hypertension (OR=1.7921; 95%
CI: 1.5091–2.1281, p<0.0001, pHet<0.0001, pE=0.2182) had higher odds to
develop AKI when infected with COVID-19.
Conclusions
Diabetes and hypertension are prominent risk factors of
acute kidney injury induced by COVID-19. |
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| ISSN: | 1105-848X 1791-4914 |