Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with Epilepsy
Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients wit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2022-09-01
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| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/article-1-562-en.html |
| _version_ | 1798030871816568832 |
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| author | Pargol Balali Seyedeh Sajedeh Marashi Elmira Agah Mahdi Shafiee Sabet Nasrin Rahimian Sajad Shafiee Abbas Tafakhori |
| author_facet | Pargol Balali Seyedeh Sajedeh Marashi Elmira Agah Mahdi Shafiee Sabet Nasrin Rahimian Sajad Shafiee Abbas Tafakhori |
| author_sort | Pargol Balali |
| collection | DOAJ |
| description | Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%.
There is still no approved medication for the treatment of this problem.
Objectives: The present study aims to assess the safety and efficacy of memantine in improving the
cognitive function of patients with epilepsy.
Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlled, parallelgroup
clinical trial, conducted in a hospital in Tehran, Iran during 2018-2019. Participants were
randomly allocated to receive memantine (5 mg/day in the first eight weeks and 10 mg/day in
the second eight weeks) or placebo in a 1:1 ratio. Participants underwent the Mini-mental State
Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Frontal Assessment Battery
(FAB) before and after the intervention. The primary and secondary measures were safety and
change in the cognitive test scores, respectively.
Results: Out of 53 allocated participants, 33 completed the study. Drug intolerance including
headache, somnolence, and dizziness was not significantly different between the two groups. The
Intention-to-Treat analyses demonstrated no significant change in MoCA and FAB scores between
the two groups after the intervention, but a significant improvement in the MMSE score of the
memantine group (P=0.047) was observed. After controlling confounding factors, there was no
significant difference in scores of any cognitive tests between the two groups.
Conclusion: Memantine is a safe drug for patients with epilepsy, but it may not exert a beneficial
effect on the cognitive function of these patients. |
| first_indexed | 2024-04-11T19:47:14Z |
| format | Article |
| id | doaj.art-9449aefcfd1445a78b42f9e2249e1878 |
| institution | Directory Open Access Journal |
| issn | 2423-4818 |
| language | English |
| last_indexed | 2024-04-11T19:47:14Z |
| publishDate | 2022-09-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-9449aefcfd1445a78b42f9e2249e18782022-12-22T04:06:24ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182022-09-0184197205Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with EpilepsyPargol Balali0Seyedeh Sajedeh Marashi1Elmira Agah2Mahdi Shafiee Sabet3Nasrin Rahimian4Sajad Shafiee5Abbas Tafakhori6 Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Family Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Department of Neurosurgery, Faculty of Medicine, Mazandaran University of Medical Sciences Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients with epilepsy. Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlled, parallelgroup clinical trial, conducted in a hospital in Tehran, Iran during 2018-2019. Participants were randomly allocated to receive memantine (5 mg/day in the first eight weeks and 10 mg/day in the second eight weeks) or placebo in a 1:1 ratio. Participants underwent the Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Frontal Assessment Battery (FAB) before and after the intervention. The primary and secondary measures were safety and change in the cognitive test scores, respectively. Results: Out of 53 allocated participants, 33 completed the study. Drug intolerance including headache, somnolence, and dizziness was not significantly different between the two groups. The Intention-to-Treat analyses demonstrated no significant change in MoCA and FAB scores between the two groups after the intervention, but a significant improvement in the MMSE score of the memantine group (P=0.047) was observed. After controlling confounding factors, there was no significant difference in scores of any cognitive tests between the two groups. Conclusion: Memantine is a safe drug for patients with epilepsy, but it may not exert a beneficial effect on the cognitive function of these patients.http://cjns.gums.ac.ir/article-1-562-en.htmlmemantineepilepsycognition disordersseizures |
| spellingShingle | Pargol Balali Seyedeh Sajedeh Marashi Elmira Agah Mahdi Shafiee Sabet Nasrin Rahimian Sajad Shafiee Abbas Tafakhori Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with Epilepsy Caspian Journal of Neurological Sciences memantine epilepsy cognition disorders seizures |
| title | Safety and Efficacy of Memantine in
Improving Cognitive Function of Patients with Epilepsy |
| title_full | Safety and Efficacy of Memantine in
Improving Cognitive Function of Patients with Epilepsy |
| title_fullStr | Safety and Efficacy of Memantine in
Improving Cognitive Function of Patients with Epilepsy |
| title_full_unstemmed | Safety and Efficacy of Memantine in
Improving Cognitive Function of Patients with Epilepsy |
| title_short | Safety and Efficacy of Memantine in
Improving Cognitive Function of Patients with Epilepsy |
| title_sort | safety and efficacy of memantine in improving cognitive function of patients with epilepsy |
| topic | memantine epilepsy cognition disorders seizures |
| url | http://cjns.gums.ac.ir/article-1-562-en.html |
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