The Role of Neuropeptides in Pathogenesis of Dry Eye
Neuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are thought to be important factors in the pathogenesi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/18/4248 |
| _version_ | 1797518673524555776 |
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| author | Daniel Duck-Jin Hwang Seok-Jae Lee Jeong-Hun Kim Sang-Mok Lee |
| author_facet | Daniel Duck-Jin Hwang Seok-Jae Lee Jeong-Hun Kim Sang-Mok Lee |
| author_sort | Daniel Duck-Jin Hwang |
| collection | DOAJ |
| description | Neuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are thought to be important factors in the pathogenesis of dry eye disease, as suggested by the well-known role between the nervous and immune systems, and several recently published studies have elucidated the previously unknown pathogenic mechanisms involved in the role of the neuropeptides secreted from the corneal nerves in dry eye disease. Here, we reviewed the emerging concept of neurogenic inflammation as one of the pathogenic mechanisms of dry eye disease, the recent results of related studies, and the direction of future research. |
| first_indexed | 2024-03-10T07:33:02Z |
| format | Article |
| id | doaj.art-944a2b9c17b1465795d848b2e6fb97d8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:33:02Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-944a2b9c17b1465795d848b2e6fb97d82023-11-22T13:41:57ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018424810.3390/jcm10184248The Role of Neuropeptides in Pathogenesis of Dry EyeDaniel Duck-Jin Hwang0Seok-Jae Lee1Jeong-Hun Kim2Sang-Mok Lee3Department of Ophthalmology, HanGil Eye Hospital, Incheon 21388, KoreaFight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul 03080, KoreaFight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Ophthalmology, HanGil Eye Hospital, Incheon 21388, KoreaNeuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are thought to be important factors in the pathogenesis of dry eye disease, as suggested by the well-known role between the nervous and immune systems, and several recently published studies have elucidated the previously unknown pathogenic mechanisms involved in the role of the neuropeptides secreted from the corneal nerves in dry eye disease. Here, we reviewed the emerging concept of neurogenic inflammation as one of the pathogenic mechanisms of dry eye disease, the recent results of related studies, and the direction of future research.https://www.mdpi.com/2077-0383/10/18/4248dry eyeneuropeptidepathogenesisneurogenic inflammationcorneal nervesubstance P |
| spellingShingle | Daniel Duck-Jin Hwang Seok-Jae Lee Jeong-Hun Kim Sang-Mok Lee The Role of Neuropeptides in Pathogenesis of Dry Eye Journal of Clinical Medicine dry eye neuropeptide pathogenesis neurogenic inflammation corneal nerve substance P |
| title | The Role of Neuropeptides in Pathogenesis of Dry Eye |
| title_full | The Role of Neuropeptides in Pathogenesis of Dry Eye |
| title_fullStr | The Role of Neuropeptides in Pathogenesis of Dry Eye |
| title_full_unstemmed | The Role of Neuropeptides in Pathogenesis of Dry Eye |
| title_short | The Role of Neuropeptides in Pathogenesis of Dry Eye |
| title_sort | role of neuropeptides in pathogenesis of dry eye |
| topic | dry eye neuropeptide pathogenesis neurogenic inflammation corneal nerve substance P |
| url | https://www.mdpi.com/2077-0383/10/18/4248 |
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