The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protei...
Main Authors: | Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-10-01
|
Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1007038 |
Similar Items
-
Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons
by: Maria I Lazaro-Pena, et al.
Published: (2023-06-01) -
Regulation of retinal axon growth by secreted Vax1 homeodomain protein
by: Namsuk Kim, et al.
Published: (2014-09-01) -
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
by: Xu Zheng, et al.
Published: (2016-11-01) -
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
by: Zheng, Xu, et al.
Published: (2017) -
Correction: Regulation of retinal axon growth by secreted Vax1 homeodomain protein
by: Namsuk Kim, et al.
Published: (2014-11-01)