Multifunctional metal–organic frameworks for wound healing and skin regeneration
Various wounds caused by burns, trauma, surgery, and genetic irregularities, including acute and chronic wounds, pose a huge burden on global healthcare. Many therapeutic strategies, such as nanomedicine and regenerative medicine, have been applied to wound repair and skin regeneration. As a promisi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523006676 |
| _version_ | 1797671477838872576 |
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| author | Fei Xing Hong Ma Peiyun Yu Yuxi Zhou Rong Luo Zhou Xiang Pol Maria Rommens Xin Duan Ulrike Ritz |
| author_facet | Fei Xing Hong Ma Peiyun Yu Yuxi Zhou Rong Luo Zhou Xiang Pol Maria Rommens Xin Duan Ulrike Ritz |
| author_sort | Fei Xing |
| collection | DOAJ |
| description | Various wounds caused by burns, trauma, surgery, and genetic irregularities, including acute and chronic wounds, pose a huge burden on global healthcare. Many therapeutic strategies, such as nanomedicine and regenerative medicine, have been applied to wound repair and skin regeneration. As a promising and exciting nanomaterial, metal–organic frameworks (MOFs) encompass many desirable properties, including crystalline porous structure, tunable size, good mechanical stability, large specific surface area, and exceptional chemical stability. Most importantly, the performance of MOFs can be modulated by changing synthesis steps and conditions. MOFs can release metal ions to modulate cellular behaviors and kill various microorganisms, which meets this dual agent release therapeutic strategy for wound healing and skin regeneration. Additionally, MOFs can act as carriers for delivering bioactive agents in a desired manner. Recently, an increasing number of researchers have conducted many studies on applying various MOFs in wound healing and skin regeneration. Based on this, we perform this study to report the current status and further perspective of MOFs-based therapeutic strategy. Furthermore, the molecular process of wound healing and the fabrication of MOFs were also discussed. |
| first_indexed | 2024-03-11T21:16:07Z |
| format | Article |
| id | doaj.art-944b7bc3fd5049a0b41831f8cf85281e |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:16:07Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-944b7bc3fd5049a0b41831f8cf85281e2023-09-29T04:43:32ZengElsevierMaterials & Design0264-12752023-09-01233112252Multifunctional metal–organic frameworks for wound healing and skin regenerationFei Xing0Hong Ma1Peiyun Yu2Yuxi Zhou3Rong Luo4Zhou Xiang5Pol Maria Rommens6Xin Duan7Ulrike Ritz8Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaLIMES Institute, Department of Molecular Brain Physiology and Behavior, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, GermanyDepartment of Periodontology, Justus-Liebig-University of Giessen, GermanyDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopaedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, GermanyDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China; Department of Orthopedic Surgery, The Fifth People's Hospital of Sichuan Province, Chengdu, China; Corresponding authors.Department of Orthopaedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany; Corresponding authors.Various wounds caused by burns, trauma, surgery, and genetic irregularities, including acute and chronic wounds, pose a huge burden on global healthcare. Many therapeutic strategies, such as nanomedicine and regenerative medicine, have been applied to wound repair and skin regeneration. As a promising and exciting nanomaterial, metal–organic frameworks (MOFs) encompass many desirable properties, including crystalline porous structure, tunable size, good mechanical stability, large specific surface area, and exceptional chemical stability. Most importantly, the performance of MOFs can be modulated by changing synthesis steps and conditions. MOFs can release metal ions to modulate cellular behaviors and kill various microorganisms, which meets this dual agent release therapeutic strategy for wound healing and skin regeneration. Additionally, MOFs can act as carriers for delivering bioactive agents in a desired manner. Recently, an increasing number of researchers have conducted many studies on applying various MOFs in wound healing and skin regeneration. Based on this, we perform this study to report the current status and further perspective of MOFs-based therapeutic strategy. Furthermore, the molecular process of wound healing and the fabrication of MOFs were also discussed.http://www.sciencedirect.com/science/article/pii/S0264127523006676Metal–organic frameworksMOFAntibacterialWound repairSkin regeneration |
| spellingShingle | Fei Xing Hong Ma Peiyun Yu Yuxi Zhou Rong Luo Zhou Xiang Pol Maria Rommens Xin Duan Ulrike Ritz Multifunctional metal–organic frameworks for wound healing and skin regeneration Materials & Design Metal–organic frameworks MOF Antibacterial Wound repair Skin regeneration |
| title | Multifunctional metal–organic frameworks for wound healing and skin regeneration |
| title_full | Multifunctional metal–organic frameworks for wound healing and skin regeneration |
| title_fullStr | Multifunctional metal–organic frameworks for wound healing and skin regeneration |
| title_full_unstemmed | Multifunctional metal–organic frameworks for wound healing and skin regeneration |
| title_short | Multifunctional metal–organic frameworks for wound healing and skin regeneration |
| title_sort | multifunctional metal organic frameworks for wound healing and skin regeneration |
| topic | Metal–organic frameworks MOF Antibacterial Wound repair Skin regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523006676 |
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