Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation
Engaging the immune sensing Stimulator of Interferon Genes (STING) pathway has emerged as a potentially powerful approach to cancer therapy. However, current STING agonists lack stability and specificity, resulting in toxic adverse effects and disappointing patient outcomes. Therefore, novel deliver...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Chemical Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchbi.2024.1386220/full |
| _version_ | 1797221710938767360 |
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| author | Sina Khorsandi Kristin Huntoon Jacques Lux |
| author_facet | Sina Khorsandi Kristin Huntoon Jacques Lux |
| author_sort | Sina Khorsandi |
| collection | DOAJ |
| description | Engaging the immune sensing Stimulator of Interferon Genes (STING) pathway has emerged as a potentially powerful approach to cancer therapy. However, current STING agonists lack stability and specificity, resulting in toxic adverse effects and disappointing patient outcomes. Therefore, novel delivery vehicles are needed to mitigate negative results and improve the efficacy of STING agonists. Here we discuss innovative particle-based strategies and how they have increased the therapeutic results seen with STING agonists. We review ultrasound-responsive vehicles, pH-responsive particles, inorganic particles, carriers for extended release, and particles that act as both STING agonists and/or drug carriers. Further optimization of these strategies can potentially enable the clinical use of STING agonists for cancer therapy. |
| first_indexed | 2024-04-24T13:09:46Z |
| format | Article |
| id | doaj.art-944f43a34c904b5abb486d3aa3780dfc |
| institution | Directory Open Access Journal |
| issn | 2813-530X |
| language | English |
| last_indexed | 2024-04-24T13:09:46Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemical Biology |
| spelling | doaj.art-944f43a34c904b5abb486d3aa3780dfc2024-04-05T04:43:32ZengFrontiers Media S.A.Frontiers in Chemical Biology2813-530X2024-04-01310.3389/fchbi.2024.13862201386220Putting the sting back in STING therapy: novel delivery vehicles for improved STING activationSina Khorsandi0Kristin Huntoon1Jacques Lux2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Neurosurgery, Emory University, Atlanta, GA, United StatesDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesEngaging the immune sensing Stimulator of Interferon Genes (STING) pathway has emerged as a potentially powerful approach to cancer therapy. However, current STING agonists lack stability and specificity, resulting in toxic adverse effects and disappointing patient outcomes. Therefore, novel delivery vehicles are needed to mitigate negative results and improve the efficacy of STING agonists. Here we discuss innovative particle-based strategies and how they have increased the therapeutic results seen with STING agonists. We review ultrasound-responsive vehicles, pH-responsive particles, inorganic particles, carriers for extended release, and particles that act as both STING agonists and/or drug carriers. Further optimization of these strategies can potentially enable the clinical use of STING agonists for cancer therapy.https://www.frontiersin.org/articles/10.3389/fchbi.2024.1386220/fullSTINGimmunotherapycancer therapydrug deliveryparticles |
| spellingShingle | Sina Khorsandi Kristin Huntoon Jacques Lux Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation Frontiers in Chemical Biology STING immunotherapy cancer therapy drug delivery particles |
| title | Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation |
| title_full | Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation |
| title_fullStr | Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation |
| title_full_unstemmed | Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation |
| title_short | Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation |
| title_sort | putting the sting back in sting therapy novel delivery vehicles for improved sting activation |
| topic | STING immunotherapy cancer therapy drug delivery particles |
| url | https://www.frontiersin.org/articles/10.3389/fchbi.2024.1386220/full |
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