Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes
Abstract Type 2 diabetes mellitus (T2DM) is a progressive disease, which affects colorectal cancer (CRC) survival. However, data on the relationship between CRC survival and T2DM duration is scarce and controversial. A retrospective observational study was conducted. Sub-cohorts were created based o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40216-3 |
| _version_ | 1797560056000020480 |
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| author | Magdolna Herold Attila Marcell Szasz Gyongyver Szentmartoni Emoke Martinek Viktor Madar-Dank Andras Jozsef Barna Reka Mohacsi Aniko Somogyi Magdolna Dank Zoltan Herold |
| author_facet | Magdolna Herold Attila Marcell Szasz Gyongyver Szentmartoni Emoke Martinek Viktor Madar-Dank Andras Jozsef Barna Reka Mohacsi Aniko Somogyi Magdolna Dank Zoltan Herold |
| author_sort | Magdolna Herold |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM) is a progressive disease, which affects colorectal cancer (CRC) survival. However, data on the relationship between CRC survival and T2DM duration is scarce and controversial. A retrospective observational study was conducted. Sub-cohorts were created based on the duration of T2DM as follows, ≤ or > 5/10/15/20 years. 204 of the 817 (24.95%) included study participants had T2DM at any point of CRC. 160 of the 204 CRC + T2DM patients had detailed T2DM duration data. At the time of CRC diagnosis, 85, 50, 31, and 11 patients had T2DM for > 5/10/15/20 years, respectively, which increased to 110, 71, 45, and 17 during the course of the study. Despite constant glycated hemoglobin values throughout the study, shorter overall and disease-specific survival times were observed for the > 5/10/15 years cohorts and longitudinal survival modeling techniques confirmed the significant effect of T2DM duration in all cohorts. While in the first 3 years after CRC diagnosis, the best survival was found for the ≤ 5 years cohort, all diabetes cohorts had the same survival thereafter. T2DM duration affected CRC survival significantly, therefore, a closer follow-up of this sub-populations is suggested. |
| first_indexed | 2024-03-10T17:54:00Z |
| format | Article |
| id | doaj.art-94500fa43279402fb1bf8e07af63e9dd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:54:00Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-94500fa43279402fb1bf8e07af63e9dd2023-11-20T09:15:13ZengNature PortfolioScientific Reports2045-23222023-08-0113111310.1038/s41598-023-40216-3Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomesMagdolna Herold0Attila Marcell Szasz1Gyongyver Szentmartoni2Emoke Martinek3Viktor Madar-Dank4Andras Jozsef Barna5Reka Mohacsi6Aniko Somogyi7Magdolna Dank8Zoltan Herold9Department of Internal Medicine and Hematology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDepartment of the Institute for Dispute Resolution, New Jersey City UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDepartment of Internal Medicine and Hematology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis UniversityAbstract Type 2 diabetes mellitus (T2DM) is a progressive disease, which affects colorectal cancer (CRC) survival. However, data on the relationship between CRC survival and T2DM duration is scarce and controversial. A retrospective observational study was conducted. Sub-cohorts were created based on the duration of T2DM as follows, ≤ or > 5/10/15/20 years. 204 of the 817 (24.95%) included study participants had T2DM at any point of CRC. 160 of the 204 CRC + T2DM patients had detailed T2DM duration data. At the time of CRC diagnosis, 85, 50, 31, and 11 patients had T2DM for > 5/10/15/20 years, respectively, which increased to 110, 71, 45, and 17 during the course of the study. Despite constant glycated hemoglobin values throughout the study, shorter overall and disease-specific survival times were observed for the > 5/10/15 years cohorts and longitudinal survival modeling techniques confirmed the significant effect of T2DM duration in all cohorts. While in the first 3 years after CRC diagnosis, the best survival was found for the ≤ 5 years cohort, all diabetes cohorts had the same survival thereafter. T2DM duration affected CRC survival significantly, therefore, a closer follow-up of this sub-populations is suggested.https://doi.org/10.1038/s41598-023-40216-3 |
| spellingShingle | Magdolna Herold Attila Marcell Szasz Gyongyver Szentmartoni Emoke Martinek Viktor Madar-Dank Andras Jozsef Barna Reka Mohacsi Aniko Somogyi Magdolna Dank Zoltan Herold Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes Scientific Reports |
| title | Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| title_full | Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| title_fullStr | Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| title_full_unstemmed | Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| title_short | Influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| title_sort | influence of the duration of type 2 diabetes mellitus on colorectal cancer outcomes |
| url | https://doi.org/10.1038/s41598-023-40216-3 |
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