Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms link...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/477 |
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| author | Marceau Quatredeniers Pedro Mendes-Ferreira Diana Santos-Ribeiro Morad K. Nakhleh Maria-Rosa Ghigna Sylvia Cohen-Kaminsky Frédéric Perros |
| author_facet | Marceau Quatredeniers Pedro Mendes-Ferreira Diana Santos-Ribeiro Morad K. Nakhleh Maria-Rosa Ghigna Sylvia Cohen-Kaminsky Frédéric Perros |
| author_sort | Marceau Quatredeniers |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH. |
| first_indexed | 2024-03-09T00:36:38Z |
| format | Article |
| id | doaj.art-945049dfff64441fba3ea7a473e5c708 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T00:36:38Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-945049dfff64441fba3ea7a473e5c7082023-12-11T18:06:05ZengMDPI AGCells2073-44092021-02-0110247710.3390/cells10020477Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the MechanismsMarceau Quatredeniers0Pedro Mendes-Ferreira1Diana Santos-Ribeiro2Morad K. Nakhleh3Maria-Rosa Ghigna4Sylvia Cohen-Kaminsky5Frédéric Perros6INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, FranceCardiovascular R&D Center, Faculty of Medicine of the University of Porto, 4200-450 Porto, PortugalInstitute of Experimental and Clinical Research (IREC), Pneumology, ENT and Dermatology, Université catholique de Louvain (UCL), 1060 Brussels, BelgiumINSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, FranceINSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, FranceINSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, FranceINSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, FrancePulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH.https://www.mdpi.com/2073-4409/10/2/477pulmonary arterial hypertensioniron deficiencycardiovascular diseaseiron homeostasis |
| spellingShingle | Marceau Quatredeniers Pedro Mendes-Ferreira Diana Santos-Ribeiro Morad K. Nakhleh Maria-Rosa Ghigna Sylvia Cohen-Kaminsky Frédéric Perros Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms Cells pulmonary arterial hypertension iron deficiency cardiovascular disease iron homeostasis |
| title | Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms |
| title_full | Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms |
| title_fullStr | Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms |
| title_full_unstemmed | Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms |
| title_short | Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms |
| title_sort | iron deficiency in pulmonary arterial hypertension a deep dive into the mechanisms |
| topic | pulmonary arterial hypertension iron deficiency cardiovascular disease iron homeostasis |
| url | https://www.mdpi.com/2073-4409/10/2/477 |
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