Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function
BackgroundWe evaluated the long-term clinical outcomes of nephrocalcinosis (NC) according to etiology and grade in preschool-age children with NC.MethodsWe retrospectively analyzed the clinical outcomes and disease grade of children with NC classified into three groups according to etiology: prematu...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1214704/full |
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| author | Hyun Ah Woo Hyeonju Lee Young Hun Choi Jeesu Min Hee Gyung Kang Hee Gyung Kang Hee Gyung Kang Yo Han Ahn Yo Han Ahn Yo Han Ahn Hyun Kyung Lee |
| author_facet | Hyun Ah Woo Hyeonju Lee Young Hun Choi Jeesu Min Hee Gyung Kang Hee Gyung Kang Hee Gyung Kang Yo Han Ahn Yo Han Ahn Yo Han Ahn Hyun Kyung Lee |
| author_sort | Hyun Ah Woo |
| collection | DOAJ |
| description | BackgroundWe evaluated the long-term clinical outcomes of nephrocalcinosis (NC) according to etiology and grade in preschool-age children with NC.MethodsWe retrospectively analyzed the clinical outcomes and disease grade of children with NC classified into three groups according to etiology: prematurity, tubular disorders, and others.ResultsOverall, 67 children were diagnosed with NC [median age, 0.76 years; interquartile range (IQR) 0.46–2.14 years]. The etiologies of NC included prematurity (28.4%), tubular disorders (25.4%), and others (46.3%). Moreover, 56 (83.6%) children were asymptomatic and diagnosed accidentally through kidney ultrasonography. Newly diagnosed underlying diseases were greater in the tubular disorders group than in the other two groups (P = 0.001). Significantly more newly diagnosed NCs were grade 3 than grade 1 (P = 0.003). The median estimated glomerular filtration rate (eGFR) changed from 96.1 (IQR 68.8–119.2) ml/min/1.72 m2 at diagnosis to 90.9 (IQR 76.4–106.4) ml/min/1.72 m2 at the last follow-up, without a significant difference (P = 0.096). Changes in the kidney function did not differ according to etiology. However, patients without improvement in NC grade showed a decrease in eGFR from 98.1 (IQR 71.1–132.9) to 87.4 (IQR 74.0–104.1) ml/min/1.73 m2 (P = 0.023), while patients with improved NC grade did not show any change in the kidney function.ConclusionsEarly recognition, especially in NC grade 3, can help uncover further diagnoses, such as tubular disorders. Long-term kidney function depends on whether the NC grade improves. |
| first_indexed | 2024-03-11T19:13:14Z |
| format | Article |
| id | doaj.art-945074f90a0c41ce91a748641236fc9f |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T19:13:14Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-945074f90a0c41ce91a748641236fc9f2023-10-09T10:07:19ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-10-011110.3389/fped.2023.12147041214704Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney functionHyun Ah Woo0Hyeonju Lee1Young Hun Choi2Jeesu Min3Hee Gyung Kang4Hee Gyung Kang5Hee Gyung Kang6Yo Han Ahn7Yo Han Ahn8Yo Han Ahn9Hyun Kyung Lee10Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaDepartment of Radiology, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of KoreaKidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of KoreaKidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of KoreaDepartment of Pediatrics, Kangwon National University Children's Hospital, Chuncheon, Republic of KoreaBackgroundWe evaluated the long-term clinical outcomes of nephrocalcinosis (NC) according to etiology and grade in preschool-age children with NC.MethodsWe retrospectively analyzed the clinical outcomes and disease grade of children with NC classified into three groups according to etiology: prematurity, tubular disorders, and others.ResultsOverall, 67 children were diagnosed with NC [median age, 0.76 years; interquartile range (IQR) 0.46–2.14 years]. The etiologies of NC included prematurity (28.4%), tubular disorders (25.4%), and others (46.3%). Moreover, 56 (83.6%) children were asymptomatic and diagnosed accidentally through kidney ultrasonography. Newly diagnosed underlying diseases were greater in the tubular disorders group than in the other two groups (P = 0.001). Significantly more newly diagnosed NCs were grade 3 than grade 1 (P = 0.003). The median estimated glomerular filtration rate (eGFR) changed from 96.1 (IQR 68.8–119.2) ml/min/1.72 m2 at diagnosis to 90.9 (IQR 76.4–106.4) ml/min/1.72 m2 at the last follow-up, without a significant difference (P = 0.096). Changes in the kidney function did not differ according to etiology. However, patients without improvement in NC grade showed a decrease in eGFR from 98.1 (IQR 71.1–132.9) to 87.4 (IQR 74.0–104.1) ml/min/1.73 m2 (P = 0.023), while patients with improved NC grade did not show any change in the kidney function.ConclusionsEarly recognition, especially in NC grade 3, can help uncover further diagnoses, such as tubular disorders. Long-term kidney function depends on whether the NC grade improves.https://www.frontiersin.org/articles/10.3389/fped.2023.1214704/fullnephrocalcinosischildrenkidney functiontubular disorderspretermkidney ultrasonography |
| spellingShingle | Hyun Ah Woo Hyeonju Lee Young Hun Choi Jeesu Min Hee Gyung Kang Hee Gyung Kang Hee Gyung Kang Yo Han Ahn Yo Han Ahn Yo Han Ahn Hyun Kyung Lee Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function Frontiers in Pediatrics nephrocalcinosis children kidney function tubular disorders preterm kidney ultrasonography |
| title | Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function |
| title_full | Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function |
| title_fullStr | Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function |
| title_full_unstemmed | Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function |
| title_short | Clinical outcomes of nephrocalcinosis in preschool-age children: association between nephrocalcinosis improvement and long-term kidney function |
| title_sort | clinical outcomes of nephrocalcinosis in preschool age children association between nephrocalcinosis improvement and long term kidney function |
| topic | nephrocalcinosis children kidney function tubular disorders preterm kidney ultrasonography |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1214704/full |
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