Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects
Patients with epilepsy carry a risk of premature death which is on average two to three times higher than in the general population. The risk of death is not homogenously distributed over all ages, etiologies, and epilepsy syndromes. People with drug resistant seizures carry the highest risk of deat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Epidemiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fepid.2023.1081757/full |
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| author | Eugen Trinka Eugen Trinka Eugen Trinka Lucas J. Rainer Lucas J. Rainer Claudia A. Granbichler Georg Zimmermann Georg Zimmermann Georg Zimmermann Markus Leitinger |
| author_facet | Eugen Trinka Eugen Trinka Eugen Trinka Lucas J. Rainer Lucas J. Rainer Claudia A. Granbichler Georg Zimmermann Georg Zimmermann Georg Zimmermann Markus Leitinger |
| author_sort | Eugen Trinka |
| collection | DOAJ |
| description | Patients with epilepsy carry a risk of premature death which is on average two to three times higher than in the general population. The risk of death is not homogenously distributed over all ages, etiologies, and epilepsy syndromes. People with drug resistant seizures carry the highest risk of death compared to those who are seizure free, whose risk is similar as in the general population. Most of the increased risk is directly related to the cause of epilepsy itself. Sudden unexplained death in epilepsy patients (SUDEP) is the most important cause of epilepsy-related deaths especially in the young and middle-aged groups. Population based studies with long-term follow up demonstrated that the first years after diagnosis carry the highest risk of death, while in the later years the mortality decreases. Improved seizure control and being exposed to a specialized comprehensive care centre may help to reduce the risk of death in patients with epilepsy. The mortality of status epilepticus is substantially increased with case fatality rates between 4.6% and 39%, depending on its cause and duration, and the age of the population studied. The epidemiological data on overall and cause specific mortality as well as their determinants and risk factors are critically reviewed and methodological issues pertinent to the studies on mortality of epilepsy and Status epilepticus are discussed. |
| first_indexed | 2024-04-10T07:54:23Z |
| format | Article |
| id | doaj.art-94518bffe4cc4c14b9373efb53b66276 |
| institution | Directory Open Access Journal |
| issn | 2674-1199 |
| language | English |
| last_indexed | 2025-03-21T02:13:58Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Epidemiology |
| spelling | doaj.art-94518bffe4cc4c14b9373efb53b662762024-08-02T17:50:14ZengFrontiers Media S.A.Frontiers in Epidemiology2674-11992023-02-01310.3389/fepid.2023.10817571081757Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspectsEugen Trinka0Eugen Trinka1Eugen Trinka2Lucas J. Rainer3Lucas J. Rainer4Claudia A. Granbichler5Georg Zimmermann6Georg Zimmermann7Georg Zimmermann8Markus Leitinger9Department of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Member of EpiCARE, Salzburg, AustriaNeuroscience Institute, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Salzburg, AustriaInstitute of Public Health, Medical Decision-Making and HTA, UMIT – Private University for Health Sciences, Medical Informatics and Technology, Hall In Tyrol, AustriaDepartment of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Member of EpiCARE, Salzburg, AustriaNeuroscience Institute, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Meir Medical Center, Kfar Saba, IsraelDepartment of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Member of EpiCARE, Salzburg, AustriaTeam Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University, Salzburg, AustriaResearch and Innovation Management, Paracelsus Medical University, Salzburg, AustriaDepartment of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Member of EpiCARE, Salzburg, AustriaPatients with epilepsy carry a risk of premature death which is on average two to three times higher than in the general population. The risk of death is not homogenously distributed over all ages, etiologies, and epilepsy syndromes. People with drug resistant seizures carry the highest risk of death compared to those who are seizure free, whose risk is similar as in the general population. Most of the increased risk is directly related to the cause of epilepsy itself. Sudden unexplained death in epilepsy patients (SUDEP) is the most important cause of epilepsy-related deaths especially in the young and middle-aged groups. Population based studies with long-term follow up demonstrated that the first years after diagnosis carry the highest risk of death, while in the later years the mortality decreases. Improved seizure control and being exposed to a specialized comprehensive care centre may help to reduce the risk of death in patients with epilepsy. The mortality of status epilepticus is substantially increased with case fatality rates between 4.6% and 39%, depending on its cause and duration, and the age of the population studied. The epidemiological data on overall and cause specific mortality as well as their determinants and risk factors are critically reviewed and methodological issues pertinent to the studies on mortality of epilepsy and Status epilepticus are discussed.https://www.frontiersin.org/articles/10.3389/fepid.2023.1081757/fullseizuresdeath ratestandardized mortality ratiocase fatalityepilepsy |
| spellingShingle | Eugen Trinka Eugen Trinka Eugen Trinka Lucas J. Rainer Lucas J. Rainer Claudia A. Granbichler Georg Zimmermann Georg Zimmermann Georg Zimmermann Markus Leitinger Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects Frontiers in Epidemiology seizures death rate standardized mortality ratio case fatality epilepsy |
| title | Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects |
| title_full | Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects |
| title_fullStr | Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects |
| title_full_unstemmed | Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects |
| title_short | Mortality, and life expectancy in Epilepsy and Status epilepticus—current trends and future aspects |
| title_sort | mortality and life expectancy in epilepsy and status epilepticus current trends and future aspects |
| topic | seizures death rate standardized mortality ratio case fatality epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fepid.2023.1081757/full |
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