A case control study of association of vitamin D levels with uterine fibroids
Objectives: To determine the association of low vitamin D levels and the occurrence of uterine fibroids. Methods: A case control study was conducted on 150 women between 20 to 55 years of age with at least one intrauterine fibroid of 2 cm3 in volume or larger in transvaginal ultrasound (TVS) or tran...
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2023-02-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/09361.pdf |
| _version_ | 1797901536804732928 |
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| author | Supriya Kapoor Sunita Maheshwari |
| author_facet | Supriya Kapoor Sunita Maheshwari |
| author_sort | Supriya Kapoor |
| collection | DOAJ |
| description | Objectives: To determine the association of low vitamin D levels and the occurrence of uterine fibroids. Methods: A case control study was conducted on 150 women between 20 to 55 years of age with at least one intrauterine fibroid of 2 cm3 in volume or larger in transvaginal ultrasound (TVS) or transabdominal ultrasound (TAS) who were compared with 150 age matched controls. Fibroid volume and vitamin D levels were measured in the study patients. The relationship of vitamin D with the occurrence and volume of uterine fibroids was determined. P < 0.05 was considered as statistically significant. Results: The mean age of the study patients were 43.4 ± 5.28 years who presented with complaints and complications of prolonged/HMB (74.67%) followed by dysmenorrhea (44.00%), pelvic/abdominal pain (38.00%), anaemia required blood transfusion (31.33%), urinary complaints (20.67%), lump in abdomen (10.67%), dyspareunia (5.33%) and infertility (5.33%). Compared to controls, vitamin D levels were significantly less in cases (16.32 ± 8.58 vs. 31.98 ± 5.33, p<0.0001). A significant negative correlation was seen between vitamin D with fibroid volume (r=-0.674, p<0.0001). Low vitamin D was found to be an independent significant risk factor of presence of uterine fibroid (OR =89.763 for deficient vitamin D and 4.733 for insufficient vitamin D, p<0.05). Conclusion: In conclusion, low vitamin D carries significantly higher chances of developing big uterine fibroids. This opens up an interesting facet of dietary intake or supplementation of Vitamin D in prevention as well as treatment of uterine fibroid in women of child bearing age. |
| first_indexed | 2024-04-10T09:02:23Z |
| format | Article |
| id | doaj.art-9454126a86e24038b5faaec3039d49cb |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-04-10T09:02:23Z |
| publishDate | 2023-02-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-9454126a86e24038b5faaec3039d49cb2023-02-21T10:35:44ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422023-02-019236136610.21276/obgyn.2023.9.2.33A case control study of association of vitamin D levels with uterine fibroidsSupriya Kapoor 0Sunita Maheshwari 1Jr -3, Department of Obs and Gynae, RNT Medical College, Udaipur, IndiaSenior Professor and Unit Head, Dept of Obs and Gynae, RNT Medical College and MB Hospital Udaipur, IndiaObjectives: To determine the association of low vitamin D levels and the occurrence of uterine fibroids. Methods: A case control study was conducted on 150 women between 20 to 55 years of age with at least one intrauterine fibroid of 2 cm3 in volume or larger in transvaginal ultrasound (TVS) or transabdominal ultrasound (TAS) who were compared with 150 age matched controls. Fibroid volume and vitamin D levels were measured in the study patients. The relationship of vitamin D with the occurrence and volume of uterine fibroids was determined. P < 0.05 was considered as statistically significant. Results: The mean age of the study patients were 43.4 ± 5.28 years who presented with complaints and complications of prolonged/HMB (74.67%) followed by dysmenorrhea (44.00%), pelvic/abdominal pain (38.00%), anaemia required blood transfusion (31.33%), urinary complaints (20.67%), lump in abdomen (10.67%), dyspareunia (5.33%) and infertility (5.33%). Compared to controls, vitamin D levels were significantly less in cases (16.32 ± 8.58 vs. 31.98 ± 5.33, p<0.0001). A significant negative correlation was seen between vitamin D with fibroid volume (r=-0.674, p<0.0001). Low vitamin D was found to be an independent significant risk factor of presence of uterine fibroid (OR =89.763 for deficient vitamin D and 4.733 for insufficient vitamin D, p<0.05). Conclusion: In conclusion, low vitamin D carries significantly higher chances of developing big uterine fibroids. This opens up an interesting facet of dietary intake or supplementation of Vitamin D in prevention as well as treatment of uterine fibroid in women of child bearing age.https://journal.barpetaogs.co.in/pdf/09361.pdfuterine fibroidsvitamin dfibroid volumesupplementation |
| spellingShingle | Supriya Kapoor Sunita Maheshwari A case control study of association of vitamin D levels with uterine fibroids New Indian Journal of OBGYN uterine fibroids vitamin d fibroid volume supplementation |
| title | A case control study of association of vitamin D levels with uterine fibroids |
| title_full | A case control study of association of vitamin D levels with uterine fibroids |
| title_fullStr | A case control study of association of vitamin D levels with uterine fibroids |
| title_full_unstemmed | A case control study of association of vitamin D levels with uterine fibroids |
| title_short | A case control study of association of vitamin D levels with uterine fibroids |
| title_sort | case control study of association of vitamin d levels with uterine fibroids |
| topic | uterine fibroids vitamin d fibroid volume supplementation |
| url | https://journal.barpetaogs.co.in/pdf/09361.pdf |
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